Characteristics and Synthetic Process of Sulfadiazine

The characteristics and synthesis process of sulfadiazine:
Sulfadiazine is white or off-white crystal or powder, odorless, tasteless, and gradually darkens when exposed to light. Slightly soluble in ethanol or acetone, insoluble in water, easily soluble in sodium hydroxide test solution or ammonia test solution, soluble in dilute hydrochloric acid.

characteristic:
The pure product of sulfadiazine is odorless and tasteless white crystal or powder, unstable under light irradiation, and the powder will gradually darken. The reaction of sulfadiazine and silver nitrate can produce external drug sulfadiazine silver, which is used to treat bacterial infections caused by burns and the like.

effect:
Sulfadiazine is a typical oral sulfonamide drug that works by inhibiting the synthesis of folic acid (essential for bacterial replication and growth).

Indications
Sulfadiazine has many indications, including urinary tract infection and otitis media caused by sensitive bacteria. Sulfadiazine can also be used to prevent acute joint rheumatism and meningococcal meningitis. Sulfadiazine is used in combination with pyrimethamine to prevent and treat toxoplasmosis. In addition, it is also effective against nocardiosis, chancroid and trachoma. Sulfadiazine is used as an adjuvant therapy for chloroquine-resistant malaria and various types of bacterial meningitis.
  
side effect
Common side effects are nausea, diarrhea, headache, fever, rash, depression, and pancreatitis.