What are the possible harms of taking ibuprofen, loxoprofen sodium and other medicines?

Acetaminophen, diclofenac sodium, ibuprofen, analgin, loxoprofen sodium, and nimesulide are commonly used antipyretic and analgesic drugs in clinical practice. They mainly produce peripheral vasodilation, Sweating and dissipating heat have an antipyretic effect, and produce analgesic effect by inhibiting the synthesis of prostaglandins in the central nervous system and blocking the impulse of pain-sensing nerve endings.

Acetaminophen
In terms of safety, acetaminophen generally has a small dose and causes adverse reactions, has little irritation to the gastrointestinal tract, and will not cause gastrointestinal bleeding. Agranulocytosis, anemia, allergic dermatitis (rash, pruritus, etc.), hepatitis or thrombocytopenia may occur in a small number of cases. Long-term large-scale medication, especially in patients with low renal function, may cause renal colic or acute renal failure (oliguria, uremia) or chronic renal failure (analgesic drug-induced nephropathy).

Ibuprofen
In terms of safety, 16% of patients who use ibuprofen for a long time may experience gastrointestinal adverse reactions, including indigestion, stomach burning, stomach pain, nausea and vomiting. Generally, there is no need to stop taking ibuprofen, and it is tolerable to continue taking it. Gastric ulcer and gastrointestinal bleeding occurred in less than 1%. Nervous system adverse reactions such as headache, drowsiness, dizziness and tinnitus may occur in 1%-3% of patients. Rare adverse reactions include lower extremity edema, renal insufficiency, skin rash, bronchial asthma, abnormal liver function, and leukopenia.

Analgin
In terms of safety, Analgin may cause allergic rash or drug fever, urticaria, and in severe cases, exfoliative dermatitis, epidermolysis bullosa and death; prolonged use can cause granular reduction (incidence rate About 1.1%), thrombocytopenic purpura, severe cases may have aplastic anemia or even death.

loxoprofen sodium
In terms of safety, loxoprofen sodium has more digestive system discomforts, such as abdominal pain, stomach discomfort, nausea, vomiting, loss of appetite, constipation, heartburn, etc. Sometimes rash, itching, edema, drowsiness, headache, palpitations, etc. may occur. Occasionally, shock, acute renal insufficiency, nephrotic syndrome, interstitial pneumonia, anemia, leukopenia, thrombocytopenia, eosinophilia, elevated aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, etc.