Efficacy and Effects of Isoproterenol

Efficacy and Effects of Isoproterenol

Isoproterenol Powder (isoprenaline) is also known as isoprenaline and pantethine. Synthetic product. β-adrenoceptor agonist. Mainly strong excitatory effect on β-receptors, but less selective for β1- and β2- receptors. Almost no effect on α-receptors. Isoproterenol CAS 7683-59-2 can significantly excite the heart, dilate blood vessels, and relax bronchial smooth muscle, especially when the bronchial smooth muscle is in spasm. Isoproterenol Raw Materials

Isopropyl inosine is a white or slightly yellow solid powder with a specific odor; soluble in water. It has been marketed in Europe, Italy, Canada, Japan and other more than 50 countries and regions, clinical efficacy is remarkable, toxic side effects are small, is a curative effect of the antiviral and immune function regulator.

Efficacy and effect

Isoproterenol is an antiviral drug that is effective against herpes, influenza and rhinovirus infections in humans. It is highly effective in patients with herpes simplex virus infection. It is believed that the antiviral efficacy of this product is due to its direct antiviral effect as well as its immune-enhancing effect. It is found that isoproterenol has the effect of enhancing the immune function of the body. It mainly enhances the cellular immune function and acts as a new immunomodulator.

Clinical studies have shown that isoproterenol can increase the proliferation of lymphocytes due to mitogenic factors, increase the production of antibodies and increase the production of cytokines such as interleukin 2 (IL-2). It has been clinically applied to polymicrobial stomatitis and focal genititis with remarkable efficacy. This product has high efficacy and low toxic side effects. Further research proved that isoproterenol can promote lymphocyte differentiation and regulate the function of lymphocytes, which has anti-HIV effect and can slow down the progress of AIDS. In addition, it has anti-aging and memory enhancement effects.

Isoproterenol has been used abroad for the treatment of various viral infections, immune system depression, CMV, EBV, influenza and upper and lower respiratory tract infections, herpes simplex, herpes zoster, measles, mumps, viral conjunctivitis; it is also used for acute and chronic hepatitis B, subacute sclerosing holoprosencephalitis (SSPE), fatigue syndrome, etc. Isoproterenol is used in Scandinavian for the treatment of AIDS.

Pharmacological effects

Isoproterenol is an antiviral agent. In addition to its direct antiviral effect, isoproterenol is also associated with its immune enhancing effect, mainly by enhancing cellular immune function. In addition, isoproterenol enhances proliferation due to mitogenic factors, increases the production of antibodies, and increases the production of lymphatic activating factors.

Preparation method

CN101863942B discloses a method for the preparation of isopropylinosine, characterized in that it comprises the steps of:

(1) reacting p-acetamido benzoic acid with dimethylaminoisopropanol to obtain dimethylaminoisopropanol-p-acetamido benzoate salt, the molar ratio of 1:1.2 of p-acetamido benzoic acid and dimethylaminoisopropanol in anhydrous ethanol or methanol, adding ethyl acetate to the reaction solution after 2-5 hours of reaction, cooling, filtering, washing and drying to obtain a white crystalline powder, i.e. dimethylaminoisopropanol-p acetylaminobenzoate;

(2) Dimethylaminoisopropanol-p-acetamido benzoate reacts with inosine to obtain isopropylinosine.