Raw Materials Mangosteen extract powder

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Mangosteen extract Powder Usage and Synthesis.

Mangosteen extract is extracted from the active ingredients of Garcinia Cambogia, containing xanthones, phenolic acids, anthocyanosides, polymeric tannins and other components.

It has good antioxidant activity, antibacterial, anti-inflammatory and anti-allergic effects.

Uses of Mangosteen extract.

The anti-inflammatory effect of mangosteen extract has been studied in animal and clinical double-blind human trials. The mechanism of action is the inhibition of cytokines (Cytokines: TNF-α, IL-1), which reduces the activity of cyclooxygenase 2 (COX2), the production of prostaglandin PGE2, and the reduction of inflammatory indicators TNF-α. The results of human trials show that The results of human trials showed that taking 600mg of 10% mangosteen extract daily for five days effectively reduced pain by 50%, which is comparable to the effects of the non-steroidal drug Nimesulide, making it the best alternative to long-term anti-inflammatory medication for patients.

Pharmacological Effect of Mangosteen extract.

1.Antioxidant effectMangosteen alcohol extract has a good cosmetic skin care effect, based on its ability to effectively remove excessive oxygen free radicals, enhance the anti-wrinkle, effectively delay the skin aging. Among them, n-butanol solvent and ethyl acetate solvent have the best antioxidant activity.

2. Antibacterial effect of mangosteen extract has a strong inhibitory effect on a variety of disease-causing microorganisms in nature. It can inhibit the growth of Staphylococcus aureus, a common dermatological pathogen, and some of its components can also inhibit methicillin-resistant Staphylococcus aureus.

The polysaccharide extract of mangosteen can stimulate phagocytosis to kill intracellular bacteria of Salmonella enteritidis, and stimulate leukocytes to play phagocytosis and bactericidal effect.

3.Anti-inflammatory and anti-allergic effects of the two mangosteen flavonoids extracted from mangosteen, α, γ-invertin, have strong anti-inflammatory activity, and can significantly inhibit the expression of nitric oxide products and dinoprostenone products as well as nitric oxide synthase in the RAW264.7 cell line model stimulated by lipopolysaccharide.

The study suggested that the two substances reduced the level of dinoprostenol mainly through the inhibition of cyclooxygenase 2 activity and nitric oxide products.

In the rat paw oedema model caused by carrageenan gum injection, a significant inhibitory effect was found after 3h treatment with α-invertegrin.

Gamma-invertin inhibited the synthesis of prostaglandins by rat nerve cells. Therefore, these two substances have good anti-inflammatory effects and can be used as precursor compounds for the development of new anti-inflammatory drugs. The study showed that 40% ethanol extract had a strong inhibitory effect on immunoglobulin E-mediated histamine release from RBL-2H3 cells.

In addition, it also had significant inhibitory effect on passive skin allergic reaction in rats, indicating that the extract of mangosteen has better antihistamine and anti-skin allergic effects.

4. Enhancement of immunity and anti-tumour effects Mangosteen extract also enhances the immunity of the body and has a good inhibitory effect on the proliferation of various human tumours.

Mangosteen polysaccharide has phagocytosis-like intracellular killing activity, involved in human immune function.

Garcinia Cambogia E has strong cytotoxic effects on various liver cancer cell lines, as well as several gastric and lung cancer cell lines.

Preparation method of Mangosteen extract.

Take fresh mangosteen pericarp after drying and crushing 6.4kg, extract with 95% ethanol reflux each 3 times, each time 2h, merge the extract under reduced pressure concentration to get mangosteen pericarp extract.

Take fresh mangosteen pulp 854g were sequentially extracted with 95% ethanol 1 time, distilled water reflux extraction 3 times, each time 2h, combined distilled water extract, concentrated under reduced pressure to get mangosteen pulp extract.

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