Amentoflavone Raw Materials Amentoflavone powder

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Amentoflavone Powder Usage and Synthesis.

Spathiphyllum biflorum has a variety of biological activities such as anti-inflammatory, antioxidant, antiviral, anti-fatty tumour, hypoglycaemic and vasodilatory, it is a kind of cyclo-oxygenase and xanthine oxidase inhibition carve, at the same time, it is a kind of discoate vinyl acetate enzyme inhibitor in vitro on Coxsackie virus and vesicular osmosis viral type has a good inhibition effect.

In the convolvulus can also be proposed spike fir biflavonoids, and the efficacy of flavonoids is multi-faceted, it is a very strong antioxidant, can be effective in scavenging oxygen free radicals in the body, such as anthocyanins, anthocyanidins can inhibit the full stage of the overflow of oleaginous peroxides, this blocking of oxidation is more than ten times as much as the ability of vitamin E. This antioxidant effect can stop the degradation of the cell, aging, and also stop the onset of cancer.

Uses of Amentoflavone.

Spathiphyllum biflavone is a common plant constituent with a variety of effects. The main effects of Spathiphyllum biflavones include: relieving cough and asthma, stopping bleeding, clearing heat and removing toxins, and dispelling wind and dampness.

It can be used to treat cough and asthma, vomiting blood, haemorrhoidal blood, bleeding from trauma, gonorrhoea, burns and fire injuries, and other diseases.

In addition, Spathiphyllum biflavonoids also have the effects of clearing heat and dampness, diarrhoea, detoxification, etc. It can be used to treat lung-heat cough, whooping cough, feverish gonorrhoea, blood in urine, eye redness and swelling pain, sores and carbuncles, scrofula and other diseases.

The dosage of Spiraea biflavones should be determined on a case-by-case basis, generally used internally in decoction, 9-15 grams each time.

Pharmacological Effect of Amentoflavone.

1、Anti-inflammatory effect

AF is able to exert anti-inflammatory effects by inhibiting numerous inflammatory factors, which contributes to the development of novel anti-inflammatory drugs. Nuclear factor-κB (NF-κB) is one of the most important transcription factors involved in the intrinsic immune response and chronic inflammatory response in mammals.

NF-κB is involved in the regulation of immune and inflammatory responses to a variety of molecules including TNF-α, interleukin (IL)-1β, IL-2, IL-6, iNOS, COX-2, chemokines, adhesion molecules, and colony-stimulating factors, etc. Activated NF-κB up-regulates these factors and triggers inflammatory responses.

2、Anti-microbial effect

AF has a significant inhibitory effect on the proliferation of influenza A virus, influenza B virus and herpes simplex virus, and it can also reduce the replication of Coxsackie B3 virus through the inhibition of fatty acid synthase.

In addition, AF can effectively inhibit Candida albicans, Brewer's yeast and Trichosporon albicans at low concentrations.

3、Anti-tumour effect

AF is an inhibitor of histone B, which is an important member of the papain family of cysteine proteases and plays an important role in the invasion and metastasis of malignant tumours. In B16F-10 melanocytoma-induced experimental lung metastasis mice, AF showed excellent oncogenic and anti-metastatic abilities.

AF treatment significantly reduced the biochemical levels of pulmonary collagen hydroxyproline, aminohexose, glucuronic acid, serum sialic acid and γ-glutamyl transpeptidase, and up-regulated the expression of the lung tissue inhibitors metalloproteinase-1 and metalloproteinase-2, which resulted in a decrease in the formation of tumour nodules and the incidence of post-tumour pulmonary fibrosis.

Ingredient of Bulk Amentoflavone Powder.

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