Agomelatine CAS 138112-76-2 Raw Materials

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Agomelatine Powder Usage and Synthesis:

Agomelatine is the world's first melatonin receptor MT1 and MT2 agonist antidepressant, developed by the French company Schweizer, for the treatment of major depressive episodes in adult patients. We know that melatonin is an endogenous neurohormone produced only at night by the anterior pituitary gland of the pineal gland and acts on melatonin receptors concentrated in the suprachiasmatic nucleus (SCN) of the hypothalamus, involved in the regulation of circadian physiological rhythms in mammals, and is a well-known timekeeper in the body, correcting the biological clock regulated by the external circadian cycle.

The molecular structure of agomelatine binds directly to the pentraxin 2c (5HT2c) receptor in the postsynaptic membrane, thus exerting its antidepressant efficacy without increasing the concentration of 5-hydroxytryptamine in the synaptic gap. This unique mechanism of action allows agomelatine to rapidly and effectively exert its antidepressant effects while minimizing the occurrence of side effects.

Pharmacokinetics of Agomelatine Powder:

Melatonin analog: Agomelatine has antagonistic effects on 5-HT2C receptors and is therefore a norepinephrine-dopamine inhibitory disinhibitor (NDDI). The drug information for Agomelatine already includes a recommendation that liver function tests are required in all patients at the start of and during treatment, and this recommendation has now been extended to include liver function tests when the drug dose is increased.
The MHRA recommends that if a patient develops signs or symptoms of potential liver damage, or if, on liver function tests, an increase in serum transaminases of more than three times the upper limit of normal (ULN) is found it should be discontinued immediately.

Clinical Application of Agomelatine Powder:

Agomelatine is a medication used to treat major depressive disorder. It works by regulating the levels of serotonin and melatonin in the brain. The raw materials used to make agomelatine include:

1. 7-methoxy-1-tetralone: This is a key intermediate used in the synthesis of agomelatine.

2. 6-nitro-2,3-dihydro-1H-inden-1-one: This is another intermediate used in the synthesis of agomelatine.

3. Lithium aluminum hydride: This is a reducing agent used in the synthesis of agomelatine.

4. Sodium borohydride: This is another reducing agent used in the synthesis of agomelatine.

5. 5-methoxytryptamine: This is a precursor to melatonin, which is a key component of agomelatine.

6. 4-chloro-3-nitrobenzoic acid: This is a starting material used in the synthesis of agomelatine.

7. Ethyl bromide: This is a reagent used in the synthesis of agomelatine.

8. Diethyl ether: This is a solvent used in the synthesis of agomelatine.

9. Methanol: This is another solvent used in the synthesis of agomelatine.

10. Hydrochloric acid: This is a reagent used in the synthesis of agomelatine.
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