Megestrol Acetate API Raw Material
Megestrol Acetate API Raw Material
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Megestrol Acetate API Raw Material

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Use and synthesis of Megestrol Acetate:
Megestrol acetate (BDH1298, SC10363) was a synthetic progesterone acetate that inhibited HegG2 with IC50 of 260μM.

Chemical properties of Megestrol Acetate:
White or yellowish crystalline powder (methanol), odorless and tasteless. Melting point 214-216℃. Soluble in acetone, slightly soluble in ethanol, ether, insoluble in water.
Megestrol Acetate tablets: Indicated for the palliative care of hormone-dependent tumors, including endometrial cancer and breast cancer.
Megestrol Acetate dispersible tablets: semi-synthetic progesterone derivatives, mainly used in the treatment of advanced breast cancer and advanced endometrial cancer, kidney cancer, prostate cancer and ovarian cancer also have some efficacy. And can improve appetite and cachexia in patients with advanced cancer.
Megestrol Acetate capsules/Soft capsules: Used to treat advanced breast cancer and advanced endometrial cancer, and has some efficacy in kidney, prostate, and ovarian cancer. And can improve the appetite and cachexia of patients with advanced tumors.

Pharmacological effects of Megestrol Acetate:
This product is a semi-synthetic progesterone derivative, which has certain inhibitory effect on hormone-dependent tumors. Its mechanism of action is the same as that of meprogesterone, which may control the development and growth of ovarian follicles by influencing the secretion of pituitary gonadotropin, thus reducing the production of estrogen. It acts on estrogen receptors, prevents their synthesis and reuse, interferes with their binding to estrogen, and inhibits the growth of tumor cells. In addition, it can antagonize glucocorticoid receptors and interfere with the interaction between steroid hormone receptors and regulatory proteins related to cell growth and differentiation.

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