Clascoterone / CB-03-01 CAS 19608-29-8 Raw Materials Powder

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Clascoterone Powder Usage and Synthesis.

Clascoterone Powder is used as an intermediate in organic synthesis and medicine. CAS number 19608-29-8 for CB-03-01 Powder , molecular formula C24H34O5, molecular weight 402.52, EINECS 685-282-9. Clascoterone Raw Materials is also called 21-hydroxy-17-(1-oxopropoxy) pregna-4-ene-3,20-dione; clapristone,  21-hydroxy-17-(1-oxopropyl (Oxygen)pregna-4-ene-3,20-dione is used as an intermediate in organic synthesis and medicine.

Application/Function of Clascoterone Powder.

Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and inflammatory pathways.

Clascoterone Powder is also being investigated as a novel treatment for androgenetic alopecia.

Clascoterone Powder is an androgen receptor inhibitor being developed as a topical cream and solution by Cassiopea (a spin-out company of Cosmo Pharmaceuticals) for the treatment of androgen-dependent skin disorders, including androgenetic alopecia and acne vulgaris. Although the exact mechanism of action of clascoterone for the topical treatment of acne vulgaris is unknown, the drug is believed to compete with the androgen dihydrotestosterone for binding to androgen receptors in the sebaceous gland and hair follicles to attenuate signalling necessary for acne pathogenesis.

Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and inflammatory pathways. In August 2020, FDA approved clascoterone for the first-in-class topical treatment of acne (acne vulgaris) in male and female patients 12 years and older. Clascoterone is also being investigated as a novel treatment for androgenetic alopecia.

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