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Phenacetin Powder Usage and Synthesis.

Phenacetin itself has no antipyretic and analgesic effect, in the body, after metabolic decomposition of acetaminophen, that is, paracetamol, to play a antipyretic and analgesic effect. Paraaminophenether was also decomposed. Paraaminophenether not only had no antipyretic and analgesic effect, but also was the main factor of the toxic and side effects of phenacetin.

The mild analgesic effect of phenacetin can generally be maintained for 3-4 hours; The synergistic effect with salicylic acid enhances the analgesic effect. Clinically, it is mainly used for relieving heat and analgesia in small animals. This product is also one of the components of APC tablets. Internal process: easy to absorb, 20-30 minutes after taking the effect. Lasting 5-6 hours, after absorption, most of phenacetin rapidly deethylates to acetaminophen (paracetamol) in the liver, showing antipyretic and analgesic effects. Later, it is mainly eliminated from urine in the form of combination. A small portion is deacetylated to produce p-aminophenethers, which change hemoglobin to methemoglobin and thus exhibit the cyanosis toxicity of phenacetin.

Uses of Phenacetin.

The antipyretic effect of phenacetin is stronger than the analgesic effect. The strength of the drug is comparable to aspirin, the effect is slow and long-lasting, and the toxicity is low. The results showed that this product and its metabolite paracetamol had antipyretic effect. Because phenacetin can not be converted into paracetamol with enzyme inhibitors, it can still show obvious antipyretic effect. Therefore, the antipyretic effect after the administration of line products is not only produced by its active product paracetamol.

Antipyretic analgesic, used to treat fever, headache, neuralgia, etc. Ingredients APC tablet, analgesic mixture also contains aspirin and caffeine. Phenacetin is reasonably considered a human carcinogen; Analgesic mixtures containing phenacetin are classified as known human carcinogens.

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Pharmacological action of Phenacetin.

Product Method of Bulk Phenacetin Powder.

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