An antiasthmatic Aminophylline Raw Powder 317-34-0

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Aminophylline Powder Usage and Synthesis.

Aminophyllinum is a commonly used bronchodilator, can directly relax the bronchial tubes and bile ducts and other smooth muscles to relieve spasm. Indirectly inhibit the release of histamine and other allergic substances; and can enhance myocardial contractility, increase cardiac output, and can have vasodilator effect on coronary arteries, but generally not used as an anti-angina drug.

There is a good diuretic effect. Its effective concentration is 10-15mg/L, more than 20mg/L can cause poisoning.Aminophylline can be poisoned by a large dose or short-term frequent use of the drug, the concentration of intravenous administration is too high or too fast can lead to poisoning.

Uses and functions of Aminophylline.

Aminophylline is mainly used for bronchial asthma and asthmatic chronic bronchitis, but also for acute cardiac insufficiency, cardiac asthma and biliary colic, etc.

Aminophylline has the same effects and uses as theophylline. The presence of ethylenediamine in the molecule enhances the bronchodilating and coronary vasodilating effects.

Pharmacological Effect of Aminophylline.

1. Relaxation of airway smooth muscle: aminophylline can relax airway smooth muscle and relieve bronchial spasm.

2. Immunomodulation and anti-inflammatory effect: small amount of aminophylline can inhibit the release of inflammatory transmitters from mast cells and relieve airway smooth muscle spasm; it can also inhibit the infiltration of eosinophils in bronchial tubes.

3. Enhance the contractility of respiratory muscle: prevent and control diaphragm fatigue and respiratory failure by improving respiratory function.

4. Excitement of respiratory centre: make respiration excited, enhance the depth of respiration, but the respiratory frequency does not increase.

5. Cardiotonic: acts on heart, antagonises adenosine, prevents excessive release of adenosine, dilates coronary arteries and peripheral blood vessels, promotes myocardial contraction, and increases cardiac output.

6. Diuretic: increase renal blood flow and glomerular filtration rate, inhibit tubular reabsorption.

Production Method of Bulk Aminophylline Powder.

Aminophylline is the compound salt of theophylline and ethylenediamine. Put the theophylline into the mixer, stir and cool, use compressed air to spray into the mixture of newly distilled ethylenediamine and distilled water, after spraying, continue stirring for 10 minutes, to get aminophylline.

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