Natural Plant Extract Artemisinin Powder

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Artemisinin Powder Usage and Synthesis.

Artemisinin is a kind of drug with the best effect in treating malaria, which is a sesquiterpene lactone drug with peroxy group extracted from the traditional Chinese medicine Artemisia annua, with the characteristics of high efficiency, quick effect, clearing heat and relieving heatstroke, reducing the deficiency heat, killing protozoa and low toxicity, etc.

Currently, the efficacy of artemisinin-based combination therapy (ACT) used for the treatment of malaria in various parts of the globe reaches more than 90 per cent, and it has been widely used in the treatment of malaria in various countries in the world.It has a powerful and rapid killing effect on the intra-red stage of Plasmodium, which can rapidly control clinical episodes and symptoms.Meanwhile, it has outstanding efficacy in chicken coccidiosis, porcine erythrocytosis, toxoplasmosis, yin deficiency fever, damp-heat jaundice, malaria of inter-day malaria, falciparum malaria, cerebral malaria and chloroquine-resistant malaria.

Uses and functions of Artemisinin.

Artemisia annua is used as an antimalarial drug, and clinical application has proved that artemisinin and its derivatives are effective against intermittent malaria and falciparum malaria, especially artemisinin A, which is more effective than other artemisinin drugs in killing and reducing the intracellular asexual bodies of malaria protozoa. It has the advantages of high efficiency, quick-acting, low toxicity and no cross-resistance with chloroquine, etc. It can be used not only for treatment but also for first aid.

It is suitable for all kinds of malaria, such as falciparum malaria, inter-day malaria, chloroquine-resistant malaria and cerebral malaria. Including the fulminant type. The most notable is dihydroartemisinin and its tablets.

The drug is 10 times more effective than artemisinin in fighting malaria, with a relapse rate of only 1.95 per cent. It was thus named one of China's top ten scientific and technological achievements in 1992. Artemisinin and its derivatives are not only an excellent antimalarial drug, but also potentially attractive prospects in the treatment of other diseases.

Animal experiments have found that artemisinin-based treatment of Schistosoma oryzae in mice has an extermination rate of up to 100%; treatment of Schistosoma haematobium in animals has an extermination rate of 33.8-99.3%. Artemisinin treatment of discoid lupus erythematosus, the total effective rate of 90%. Treatment of dengue fever, the efficacy of the treatment is significantly better than the morpholino and other Western drugs.

Immunologists in the study also found that artemisinin can significantly increase the conversion rate of lymphocytes, enhance the immune function of antibodies. It has not been found to have toxic effects on heart, liver and kidney. There are no obvious side effects in the clinic.

Pharmacological Effects of Artemisinin.

Artemisinin is a sesquiterpene lactone drug with a peroxy group extracted from the traditional Chinese medicine Artemisia annua. Its effect on the ultrastructure of Plasmodium falciparum red end stage, mainly Plasmodium falciparum membrane system structure change, the drug first act on the food vesicle membrane, surface membrane, mitochondria, endoplasmic reticulum, in addition to the chromatin in the nucleus also has a certain effect.

It is suggested that the mode of action of artemisinin mainly interferes with the function of the surface membrane-mitochondria. It is possible that artemisinin acts on the food vesicle membrane, thus blocking the earliest stage of nutrient uptake, causing Plasmodium to experience amino acid starvation relatively quickly,forming autophagic vesicles rapidly and continuously discharging them out of the worm's body, so that Plasmodium loses a large amount of cytoplasm and dies.

The uptake of tritium-labelled isoleucine by P. falciparum cultured in vitro also suggests that its mode of initiation may be inhibition of protoplasmic protein synthesis.

Production Method of Bulk Artemisinin Powder.

Extracted from the leaves of the traditional Chinese medicine Artemisia annua (Artemisia annua L, Asteraceae). In addition to artemisinin, China also produces artemether and sodium artemisinate.

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