Pharmaceutical raw materials Triamcinolone Acetonide Powder

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Triamcinolone Acetonide Powder Usage and Synthesis.

Triamcinolone acetonide is a long-acting glucocorticoid drug widely used in dermatology in China, also known as triamcinolone acetonide, deinflamethasone, coninectin, conalax cream, conalax-A, belongs to the adrenocorticotropic hormone drugs, for the derivatives of triamcinolone (deinflamethasone), the action is similar to triamcinolone, with anti-inflammatory, anti-allergic, anti-pruritic and contraction of capillaries, the effect of its water-sodium retention is weak Its sodium retention effect is weak, and anti-inflammatory, anti-allergic effects than hydrocortisone (10-30 times), prednisone strong and long-lasting, aerosol inhalation treatment of bronchial asthma, the role of strong and long-lasting. The efficacy of local effects is better than triamcinolone.

Uses and functions of Triamcinolone Acetonide.

Trimethoprim is an adrenocorticotropic hormone that, when used externally, has anti-inflammatory, anti-allergic, and antipruritic effects, and is able to eliminate local non-infectious inflammation that causes fever, redness, and swelling.

Prolonged use may cause local skin atrophy, capillary dilatation, hyperpigmentation and infection.

Use during pregnancy may increase the incidence of placental insufficiency and foetal cleft lip and palate.

Clinically, tretinoin is mainly used for the treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus, and other skin diseases and pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic lumbar and leg pain, peri-acute, tenosynovitis, inflammation of the ophthalmology, oral mucosal congestion, vesiculoblastic surfaces, ulcers, and granulomatous labiitis, Chronic infectious diseases of the oral mucosa, can also be used for local injection of keloid, cystic acne, discoid lupus erythematosus, pemphigus and other small area damage.

Trimethoprim Acetate Nasal Spray is used for the prevention and treatment of perennial and seasonal allergic rhinitis and vasodilatory rhinitis.

Intra-articular injections eliminate inflammation and provide relief from pain, swelling or stiffness.

Pharmacological Effect of Triamcinolone Acetonide.

1. Anti-inflammatory effects Trimethoprim has strong and long-lasting anti-inflammatory and antimetabolic effects, and can be used topically. The potency of the drug is equivalent to prednisolone and hydrocortisone.

It can reduce congestion, reduce capillary permeability; inhibit the migration of granulocytes, lymphocytes, macrophages to the site of inflammation; prevent inflammatory mediators such as kinins, histamine, slow response substances release reaction; inhibit phagocytosis, stabilise lysosomal membranes; and prevent complement from participating in the inflammatory response.

It can reduce the symptoms of acute inflammation and inhibit the repair of post-inflammatory tissue damage to prevent scar formation.

2. Immunosuppressive effect of this drug can reduce autoimmunity, dissolve and deplete lymphocytes in lymph nodes, spleen and thymus, especially 9 lymphocytes.

Inhibit the phagocytosis and processing of antigen by macrophages. Decrease the role of the reticuloendothelial system to remove granular resistant or degenerate cells.

3. Antitoxin effect Tretinoin can non-specifically improve the stress capacity of the body, resist harmful stimuli, reduce the damage of bacterial endotoxin to the body, relieve the symptoms of toxaemia, reduce the release of endogenous pyrogens, and have antipyretic effect on toxaemia.

Trimethoprim can increase the content of erythrocytes and haemoglobin, elevate the platelet count and increase the concentration of fibrinogen, shorten the clotting time, and reduce the blood eosinophil and lymphocyte count.

4.Effect on metabolismThis drug has glucocorticoid effect, which can raise blood sugar and promote protein decomposition and other effects.

However, the activity of hydrocorticosteroid is low, and it has no effect on the water-electrolyte balance, and its effect of potassium excretion, sodium preservation and water storage is significantly weaker than that of hydrocortisone.

Contraindication of  Bulk Triamcinolone Acetonide Powder.

It is contraindicated in people who are allergic to tretinoin and steroid hormones. It is generally contraindicated in patients with the following diseases, and should be used on balance in special cases, with attention to the possibility of deterioration of the condition: severe psychosis (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, trauma repair period, corneal ulcers, hyperadrenocorticism, hypertension, diabetes mellitus, pregnant women, infections uncontrolled by antimicrobials such as chickenpox, measles, mycobacterial infections, and more severe osteoporosis.

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