Antipyretic Analgesics Drugs Carbasalate calcium Raw Materials powder

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Carbasalate calcium powder Usage and Synthesis.

Carbapyrine calcium is used for fever caused by the common cold or influenza, and is also used to relieve mild to moderate pain such as headache, joint pain, migraine, toothache, muscle pain, neuralgia, dysmenorrhea.

Uses of Carbasalate calcium powder.

It has antipyretic and analgesic effects and is used in the treatment of pain and febrile diseases. Use: For fever, pain and inflammation caused by various reasons. It can also be used for kidney swelling and urate deposition in chickens. It can relieve the symptoms of unknown high fever of pig, chicken influenza, atypical Newcastle disease, infectious bursitis, infectious bronchitis, and has an auxiliary therapeutic effect. Alias: Aspirin calcium urea; Calcium urea acetylsalicylate.

Pharmacological action of Carbasalate calcium powder.

It has antipyretic and analgesic effects. Since it does not contain sodium, it can also be used for those who prohibit sodium. Compared with similar drugs, the digestive tract is well tolerated, and stomach pain rarely occurs. The concentration of acetylsalicylic acid reached its peak after 20 minutes and reached its peak after 1 hour. The distribution of this product conforms to the two-compartment open model. The salicylate is mostly bound to plasma protein, and is mainly bound and hydroxylated in the liver to form inactive metabolites, which are excreted by the kidney. The elimination half-life was prolonged with increasing dose.

Preparation method of Bulk Carbasalate calcium powder.

A method for preparing carbapyrine calcium comprises the following steps,

(1) Add aspirin to alcohol solvent, stir at 5 ~ 10℃, slowly add ammonia water, adjust the pH value to 6 ~ 8.5, then add anhydrous calcium nitrate, temperature rise to 30 ~ 40℃, reaction 1 ~ 1.5 hours;

(2) Urea was added to the reaction liquid prepared in step (1) and reacted at 25-35 ℃ for 20-40 minutes; (3) The reaction liquid prepared in step (2) was cooled to 0 ~ 5℃, stood for crystallization 0.5-1.5 hours, pumped and filtered, and vacuum dried at 40 ~ 45℃ for 1.5-2.5 hours to obtain carbapyrine calcium.

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