Antipyretic Analgesics Ofloxacin Raw Materials powder

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Ofloxacin powder Usage and Synthesis.

Ofloxacin has the third-generation quinolone antibacterial activity, and has good antibacterial effect on Staphylococcus, streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, citrobacter, Shigella, Klebsiella pneumoniae, Enterobacter, Serratia, Proteus, Haemophilus influenzae, acinetobacter, Campylobacter, etc. It also has certain antibacterial effect on Pseudomonas aeruginosa and Chlamydia trachomatis, as well as anti-mycobacterium tuberculosis, and can be used with isoniazid and rifampicin to treat tuberculosis. It has strong antibacterial effect on gram-positive and gram-negative bacteria. It also has good effects on anaerobic bacteria and mycoplasma pneumoniae. The antibacterial activity against Staphylococcus aureus and hemolytic streptococcus is 4 ~ 8 times stronger than that of floxacin.

Uses and functions of Ofloxacin.

The third generation quinolones have the advantages of wide antibacterial spectrum, strong antibacterial activity, good bioavailability, safe and effective oral administration, low toxicity and no drug resistance. It has good antibacterial action against a variety of gram-positive and gram-negative bacteria, and also has antibacterial action against Pseudomonas aeruginosa and chlamydia. It has good effect on the strains resistant to neopenicillin, clolincomycin, gentamicin and the strains resistant to floxacin, and has no cross resistance. In addition, it also has a certain antibacterial effect on anaerobic bacteria. It is used for respiratory system infection, intestinal infection, skin soft tissue infection and urinary system infection caused by sensitive bacteria.

Drug interaction of Ofloxacin.

Ofloxacin is widely used in combination with other antibiotics, antipyretic and analgesic drugs, antiviral drugs and immunomodulators. According to market research, some provinces and cities have approved more compound ofloxacin preparations, such as ofloxacin diclofenac sodium injection, ofloxacin hydrochloride levamisole tablets, etc., to expand the antibacterial spectrum for comprehensive prevention and control, especially for other antibiotics with relatively poor efficacy of streptococcus, pneumococcus, mycoplasma, anaerobic bacteria and other good effects. The common compatible drugs are: ① with Astragalus polysaccharide, Radix isatis or Senecionis and other antiviral drugs, used for bacterial and viral infection; (2) Combined with antipyretic and analgesic drugs such as anaijin or diclofenac sodium, ketoprofen, for bacterial fever; ③ with houttuynia, bupleurum and other traditional Chinese medicine, used for summer fever; ④ Combined with metronidazole, for severe anaerobic bacterial infection; ⑤ Combined with doxycycline hydrochloride and sulfonamides, it is used for blood protozoosis; ⑥ It is compatible with dysentery and berberine for intestinal diseases.

Product method of Bulk Ofloxacin.

Using 2, 3, 4-trifluoronitrobenzene as starting material, the product was prepared by selective alkali hydrolysis, etherification, reduction, condensation, cyclization and hydrolysis with C2H5OCH=C(COOEt)2 or (CH3)2NCH=C(COOEt)2, reaction with boron acetate, and then introduction of n-methylpiperazine.

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