Meloxicam Raw Materials Powder USP BP EP

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Meloxicam Raw Materials Usage and Synthesis.

Meloxicam Raw Materials Powder USP BP EP anti-inflammatory drug, ISO China 99% Raw Material Meloxicam Powder, Pharmaceutical Raw Material Meloxicam Powder CAS 71125-38-7. 

Meloxicam is a non-steroidal antipyretic, analgesic and anti-inflammatory drug, not a hormone drug, with strong anti-inflammatory, analgesic and antipyretic effects, can selectively inhibit the activity of cyclo-oxygenase-2 (COX-2), thereby blocking prostaglandin synthesis, the inhibitory effect of prostaglandin biosynthesis in the site of inflammation is stronger than that on the gastric mucosa or the kidneys of prostaglandin biosynthesis, compared with the other NSAID more safety. It is safer than other NSAIDs.

Uses and functions of Meloxicam Raw Powder.

Meloxicam Raw Materials is mainly used to relieve the symptoms of osteoarthritis, painful osteoarthritis, rheumatoid arthritis and arthritic spondylitis.

Meloxicam Raw Powder has analgesic, anti-inflammatory and antipyretic effects and is clinically indicated for the symptomatic treatment of rheumatoid arthritis and painful osteoarthritis.

Pharmacological Effects of Meloxicam Powder.

• 1.Analgesic effects Like other non-steroidal anti-inflammatory drugs, Meloxicam is mainly used for mild and moderate chronic dull pain, such as neuralgia, arthralgia and so on.
• It has strong and long-lasting analgesic effect on inflammatory pain in experimental rats.
• Meloxicam has strong and long-lasting analgesic effect on inflammatory pain, oral dose up to 10mg-kg-1, no effect on the central nervous system, similar to indomethacin, Meloxicam has no analgesic effect on visceral pain.
• 2.Antipyretic effect Meloxicam can reduce the body temperature of febrile patients, but it has almost no effect on the normal body temperature. For example, within the anti-inflammatory dose range, meloxicam has no effect on the normal body temperature of rats, but can reduce the yeast-induced fever.

• It has a significant hypothermic effect, and the optimal antipyretic dose is 0.3mg-kg-1. twice a week.
• 3.Anti-inflammatory effect in animal inflammation models (mainly including carrageenan gum, white clay-induced murine hind paw oedema model implanted in cotton wool murine granuloma model; carrageenan gum-induced pleurisy and liquid paraffin as an adjuvant to Mycobacterium tuberculosis-induced arthritis model), Meloxicam has shown a strong anti-inflammatory activity.

Production method of Meloxicam Powder.

Meloxicam can be synthesised by a variety of methods. Commercially available sodium saccharin (without purification and drying) was used as the starting material, and condensed with methyl chloroacetate in DMF to form 2, 2 in refluxing methanol sodium methanol solution instantly expanded ring rearrangement to obtain 3, and then N-methylation, the resulting 4 and 2-amino-5-methylthiazole reaction, that is, the crude 1, and then 1,2-dichloroethane recrystallisation can be obtained in the content of ≥ 99% of the pure product, with an overall yield of 48.6%.

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