Minocycline HCl Raw Materials Powder CAS 13614-98-7

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Minocycline HCl Powder Usage and Synthesis.

The mechanism of action of Minocycline Hydrochloride is to bind to the subunit 30S of the ribosome, preventing the elongation of the peptide chain and thus preventing protein synthesis.

As a broad-spectrum antibacterial tetracycline antibiotic, it has a wider antimicrobial spectrum than its counterparts, with strong inhibitory effects on Gram-positive bacteria, including tetracycline-resistant Staphylococcus aureus, Streptococcus, etc., and on Neisseria gonorrhoeae among the Gram-negative bacteria.

It is widely used clinically in the treatment of cured sores, non-gonococcal urethritis and other infectious diseases.

Uses and functions of Minocycline HCl.

Antimicrobial. The antimicrobial spectrum and antimicrobial mechanism are the same as tetracycline, and its antimicrobial effect is significantly stronger than that of gentamycin, tetracycline, hygromycin, and also stronger than doxycycline and metacycline. Golden grapes are not easy to produce drug resistance to this product. Tetracycline-resistant Staphylococcus aureus, Streptococcus aureus and Escherichia coli may be sensitive to this product.

Pharmacological Effects of Minocycline HCl Raw.

1. Since minocycline can reduce the activity of thromboplastin, the dose of anticoagulant should be reduced when this product is used in combination with anticoagulant drugs.

2. Since acid-forming drugs (such as sodium bicarbonate) can reduce the absorption and activity of this product, this product and acid-forming drugs should be avoided at the same time.

3. When combined with drugs containing aluminium, calcium, magnesium and iron ions, it can form insoluble complexes and reduce the absorption of the product.

4. When the lipid-lowering drugs cholestyramine or colestipol are used in combination with this product, the absorption of this product may be affected.

5. Because barbiturates, phenytoin or carbamazepine can induce the activity of microsomal enzymes leading to a decrease in the blood concentration of this product, so the dose of this product must be adjusted when used in combination.

6. The combination of general anaesthetic methoxyflurane and this product may lead to fatal nephrotoxicity.

7. Because minocycline can interfere with the bactericidal activity of penicillin, the combination of this product and penicillin should be avoided.

8. The combination of this product with strong diuretics (e.g. furosemide, etc.) may aggravate renal damage.

9. Combination of this product with other hepatotoxic drugs (such as anti-tumour chemotherapy drugs) can aggravate liver damage.

10. Combination of this product and oral contraceptives can reduce the effect of oral contraceptives.

Production method of Bulk Minocycline HCl Powder.

Minocycline is obtained by azide salt derivatisation or esterification using 6-desmethylchrysin as raw material.

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