Ethinyl Estradiol Powder CAS 57-63-6 Powder Raw Material

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Ethinyl Estradiol Powder Usage and Synthesis:

Ethinyl Estradiol is an orally bioavailable estrogen that is used in almost all formulations of modern combined oral contraceptive pills. Ethinyl Estradiol Powder CAS 57-63-6 Raw Material is an orally bioavailable estrogen, Ethinyl Estradiol Raw Material is used in almost all formulations of modern combined oral contraceptive pills. Ethinyl Estradiol Powder is a white to creamy white crystalline mitochondrial Estradiol powder. Transcript levels of genes encoding cytochrome oxidase subunits I, II and III. Ethinyl estradiol is also called ethinyl estradiol clinically, the main component is estrogen, and can be used for the treatment of diseases in patients with reduced estrogen. The diseases commonly used to treat with this drug mainly include infertility caused by amenorrhea caused by insufficient secretion of estrogen, infertility caused by polycystic ovary syndrome, menopausal syndrome, senile vaginitis, endometriosis Treatment of diseases such as position syndrome, pituitary tumor, hypersecretion of androgen, etc. It also has a certain therapeutic effect on some special patients with advanced breast cancer and advanced prostate cancer.

Pharmacokinetics of Ethinyl Estradiol Powder:

This drug is a potent estrogen, with an activity of 7-8 times that of estradiol and 20 times that of diethylstilbestrol. The drug has positive and negative feedback effects on the hypothalamus and pituitary gland. Small doses can stimulate the secretion of gonadotropins, while large doses can inhibit their secretion, thereby inhibiting ovulation of the ovary and playing an anti-fertility effect. EthinylEstradiol significantly increases the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg of protein in the mitochondria and nucleus, while the percentage of oxidized forms of total glutathione is not affected. White to milky white crystalline powder. Melting point 145-146 ° C (semi-hydrate). 182-184°C (anhydrous). Soluble in ethanol, propanol, ether, chloroform, dioxane, vegetable oil and sodium hydroxide solution, almost insoluble in water. Odorless.

medicine interactions:

1. Vitamin C: Oral administration of 1g of vitamin C can increase the bioavailability of this drug to 60%-70%.

2. Progesterone drugs: combined use has a synergistic effect on inhibiting ovulation.

3. Tricyclic antidepressants: A large amount of estrogen can increase the adverse reactions of antidepressants and weaken their efficacy.

4. Carbamazepine, phenobarbital, phenytoin, primidone, rifampicin: combined use can weaken the efficacy of estrogen.

5. Anticoagulants: Estrogen can weaken the efficacy of anticoagulants. When it must be used in combination, the dose of anticoagulant should be adjusted.

6. Antihypertensive drugs: combined use can reduce the antihypertensive effect of antihypertensive drugs.

Clinical Application of Ethinyl Estradiol Powder:

Ethinyl estradiol, commonly used in the form of tablets. For female hypogonadism, climacteric syndrome, advanced breast cancer and advanced prostate cancer in postmenopausal women. Ethinyl estradiol cyproterone tablets, trade name Diane-35, is one of the more commonly used contraceptives. In addition to the effect of contraception, it also has the effect of anti-androgen and regulating menstruation. It is the first choice for the treatment of polycystic ovary syndrome. Drugs similar to it include Marfulon and Yasmin. These drugs are collectively referred to as short-acting oral contraceptives, which are widely used and reasonable types of contraceptives. In addition to contraception, these drugs can also treat some gynecological diseases and adjust menstruation. Long-term oral administration of such drugs can reduce the risk of ovarian cancer and even endometrial cancer. However, ethinyl estradiol and cyproterone tablets have certain side effects, mainly because there is a lot of water in the human tissue during the medication, which leads to obesity or facial edema of the person taking the medication.

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