Levosulpiride Raw Materials Powder

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Levosulpiride Raw Materials Usage and Synthesis.

Levosulpiride is a selective D2 dopamine receptor antagonist used as an antipsychotic and prokinetic agent. It is a colourless crystalline powder, odourless. Insoluble in methanol, ether, chloroform, benzene or water. Levosulpiride is the levorotatory form of Sulpiride, which has similar effects and uses, but the dosage of Levosulpiride is only half or less, and thus the toxic side effects are also small.

Uses and functions of Levosulpiride Raw Powder.

Overall, Levosulpiride Raw Materials is a very useful antigastric acid medication that plays an important role in the treatment of digestive disorders. Levosulpiride is available in a variety of types and preparation conditions, requiring the use of high purity raw materials and strict control of reaction conditions, purification and drying. As scientists continue to study Levosulpiride, we believe that it will play an even more important role in the future and make greater contributions to human health.

Pharmacological Effects of Levosulpiride Powder.

Levosulpiride Raw Powder is an antipsychotic drug used in the treatment of schizophrenia, and is also used for intractable vomiting, peptic ulcers, and vertigo and headache after traumatic brain injury.

Production method of Levosulpiride Powder.

• The preparation is the same as that of sulpiride, except that 2-aminomethyl-1-ethylpyrrolidine is chemically split to give the S-form before reacting with methyl 2-methoxy-5-sulfamoylbenzoate. The racemic 2-aminomethyl-1-ethylpyrrolidine was added dropwise to an aqueous solution of D-(-)-tartaric acid at room temperature with stirring. Anhydrous ethanol was then added and left in the refrigerator overnight. The solid was collected by filtration, refluxed with methanol, filtered hot and dried to give the tartaric acid salt in 36.8% yield. The salt and aqueous sodium hydroxide solution were stirred at room temperature and extracted with chloroform.
• The extract was dried, concentrated and distilled under reduced pressure to collect the fraction at 65 °C/2.0 kPa to give (S)-(-)-2aminomethyl-1-ethylpyrrolidine in 43.5% yield.
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• The obtained pyrrolidine of type S, and methyl 2-methoxy-5-sulfamoylbenzoate in ethylene glycol were stirred at 120 °C. Cooled to 5°C and filtered, the crude obtained was recrystallised with 95% ethanol to give levosulpiride in 72.6% yield, melting point 184-186°C, [α]D23-66.4° (C=0.5, dimethylformamide).

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