Adapalene Raw Material Powder CAS 106685-40-9

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Adapalene Raw Material Powder Usage and Synthesis:

Adapalene is the first-choice drug for acne treatment, we are Adapalene Raw Material Powder manufacturer and exporter in China, providing high-purity adapalene raw material powder for global customers, selling at factory price.Adapalene Raw Material Powder is a new naphthalene Formic acid derivative drugs were first launched in France in June 1996. The trade name of Adapalene Raw Material Powder is "Differin". It is mainly used to improve inflammatory skin lesions, regulate the differentiation of hair follicles and sebaceous gland epithelial cells, and treat acne. The transdermal absorption rate of Adapalene Powder is very low; in clinical trials, the concentration of adapalene in long-term use on the skin of large acne affected areas was so low that it could not be detected. Adapalene is a retinoid compound, which has been proved to have anti-inflammatory properties in in vivo and in vitro inflammatory models. It has a stable chemical structure and is not easy to decompose under air and light.

Pharmacokinetics of Adapalene Raw Material Powder :
The mechanism of action of Adapalene Raw Material Powder is to reduce the formation of micro-comedone by normalizing the hair cells on the hair follicle. In standard anti-inflammatory assays in vivo and in vitro. The efficacy of Adapalene Powder is better than that of retinoic acid. It can inhibit the chemotaxis of human multinucleated leukocytes, and can inhibit the metabolism of polymorphonuclear cells by inhibiting the transformation of arachidonic acid into inflammatory mediators through lipid oxidation. Thereby alleviating the inflammatory response mediated by the cellular response. Adapalene Powder is indicated for the treatment of cutaneous acne vulgaris characterized by comedones, papules and pustules. It can also be used to treat acne on the face, chest and back.

Clinical Application of Adapalene Raw Material Powder :
Adapalene has a stable chemical structure and is not easily decomposed in air and sunlight. Extensive animal and human studies have not found phototoxicity and photosensitivity. However, the safety of adapalene in animals and humans is not known when they are repeatedly exposed to sunlight or ultraviolet radiation. Excessive sun exposure and ultraviolet radiation should be avoided when using this product. The transdermal absorption of adapalene is very low, so the interaction with systemic drugs is unlikely to occur. The retinoic acid analog, adapalene, is a RARβ, and RARγ receptor agonist. Adapalene inhibits cell proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene gel is an effective acne treatment.

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