Usnic Acid Raw Materials Usnic Acid Powder

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Usnic Acid Powder Usage and Synthesis.

Pinusolidic acid is a powerful antibiotic of the furan group, which is cyclotropic and is found in lichens in both (+) and (-) forms. It has been reported that in the 1960s in the former Soviet Union, turpentine was made into various dosage forms and widely used in the treatment of wounds, burns, chafing and other conditions.

Because of its strong antibacterial, antiradical and antiseptic effects, Pinusolidic acid is now used in the pharmaceutical, perfume and cosmetic industries and is added as a pure substance to toothpaste, mouthwash, deodorant, sunscreen and weight loss products.

In recent years, the research on pine rosmarinic acid focuses on antibacterial, antiviral, insecticidal, anti-tumour, anti-inflammatory and so on.

Uses and functions of Usnic Acid.

1. Application in clinic: daily oral 0.1-1.0g of pine rosmarinic acid sodium salt, can make people's pulmonary tuberculosis, intestinal tuberculosis, some symptoms such as cough, loss of appetite, fever or intestinal tuberculosis diarrhoea and so on to get better, and even make tuberculosis bacilli microscopic examination to turn negative.

It can also be used for septic wounds, burns and skin infections.

2. Application in environmental monitoring: Paraquat (a kind of extremely poisonous herbicide) can transfer electrons to O2 from different transport systems and produce superoxide radicals.

Paraquat was used to treat 2 types of lichens, small wrinkled plum coat and smooth plum coat, and then the content of rosmarinic acid in the 2 types of lichens was measured by HPLC.

As a result, the content of pineolic acid increased by 36.3% in smooth plum lichen and 13.7% in small wrinkled plum lichen. They concluded that the action of rosmarinic acid was dependent on the different lichen species.

This study provides directions for the application of Pinusolidic acid in pharmaceutical and cosmetic fields and environmental biomonitoring.

3. In other applications: In recent years, it has been found that Pinusolidic acid has analgesic and antipyretic effects, and its efficacy can be compared with that of aminopyralid (antipyretic), pau d'arco (anti-inflammatory and analgesic), and hydrocortisone hemisuccinate.

It has also been found to have similar effects to antiviral, antiprotozoal, antiproliferative activity and anti-inflammatory drugs.

Intravenous injection of 10mg/kg of sodium pinealate can rapidly and significantly enhance respiration in anaesthetised cats, increase ventilation for a longer period of time, increase oxygen consumption, and elevate body temperature, all of which indicate that its metabolism is enhanced, and that it has effects similar to those of dinitrophenol, and that it is more toxic than dinitrophenol.

Because of its antimicrobial effect, Pinusolidic acid can be applied as an antiseptic.

Pharmacological Effect of Usnic Acid Powder.

1. Antibacterial effect: Pinellic acid can effectively inhibit the growth of Gram-positive bacteria such as Staphylococcus aureus, MRSA, Acinetobacter, Corynebacterium, and can inhibit the growth of Mycobacterium bovis, directly kill the cells of Staphylococcus aureus, and impede the Pseudomonas aeruginosa signaling pathway, suggesting that Pinellia extracts and Pinellic acid can be used for the treatment of acne, rosacea, seborrhoeic dermatitis, and other related dermatological disorders; in addition, it has an eliminating effect on sa-resistant plasmid. In addition, Pinus sylvestris acid has an elimination effect on SA drug-resistant plasmid, the elimination rate is 52% in 24h, and the elimination rate is up to 14.6% in 48h, which may be used for clinical treatment of drug-resistant SA infections.

2. Antiviral effect: Studies have proved that pineolic acid has the potential activity of inhibiting the proliferation of rat polyomavirus, which is mainly through the inhibition of the formation of messenger RNA, thus indirectly inhibiting the replication of DNA.

Pinus sylvestris has inhibitory activity against Epstein-barrvirus (EBV), with (+)-pinus sylvestris showing the highest inhibitory activity (ED501.0 μg/mL) and (-)-pinus sylvestris showing weaker inhibitory activity (ED505.0 μg/mL).

Adverse Reaction of Bulk Usnic Acid Powder.

One of the more significant side effects of turpentine is the allergic reaction to contact dermatitis.

In early studies, it was found that allergic reactions occurred mainly in factory workers, lichen pickers or horticulturalists who came into contact with forest timber, lichen plants, etc. In recent years, it was found that a patch test was carried out on four patients suffering from atopic dermatitis who used or came into contact with deodorants containing lichen extract, lichenic acid mixtures, and d-pinitraenoic acid, and the results showed that all four patients had positive reactions, suggesting that perfumes, cosmetics, deodorants, preservatives, and other products containing pinitraenoic acid and some other lichen plant extracts may cause contact dermatitis. The results showed that all four patients had positive reactions, suggesting that perfumes, cosmetics, deodorants and antiseptics containing d-pinacolate and some other lichen extracts may cause contact dermatitis, but that d-pinacolate does not cause photosensitisation.

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