Atorvastatin Calcium CAS 134523-03-8 Raw Materials Powder

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Atorvastatin Calcium Powder Usage and Synthesis:

Atorvastatin Calcium is A hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. It mainly inhibits the synthesis of HMGCoA reductase, thereby inhibiting the synthesis of cholesterol in the body and reducing the content of serum low density lipoprotein cholesterol and triglyceride.
Because atorvastatin calcium inhibits cell synthesis of cholesterol, interferes with the production of lipoprotein, reduces serum total cholesterol level, effectively reduces serum triglyceride level, and also increases serum HDL cholesterol level.

Atorvastatin Calcium Powder is white or quasi-White crystalline powder, insoluble in aqueous solution with pH 4 or less, slightly soluble in water, phosphate buffer solution with pH 7.4, acetonitrile, slightly soluble in ethanol and easily soluble in methanol.

Applications of Atorvastatin Calcium Powder:

Atorvastatin Calcium Powder is a cholesterol-lowering drug that belongs to the statin class.Atorvastatin Calcium Raw Materials reduces blood cholesterol levels by inhibiting the activity of cholesterol synthase and reducing the liver's ability to synthesize cholesterol.Atorvastatin Calcium CAS 134523-03-8 can be used to treat conditions such as hypercholesterolemia and hyperlipidemia and to prevent cardiovascular disease. Common side effects include abnormal liver function, muscle pain and digestive discomfort.

Pharmacological Effect of Atorvastatin Calcium Powder:

Atorvastatin Calcium Powder can reduce plasma LDL cholesterol levels in certain homozygous familial hypercholesterolemia patients who rarely respond to other lipid-lowering agents. Clinical application for primary hypercholesterolemia, mixed hyperlipidemia, hypertriglyceridemia, homozygous familial hypercholesterolemia and prevention of atherosclerosis.

Statins are A class of hypolipidemic drugs developed in the late 1980s, which are hydroxymethylglutaryl CoA (HMG-CoA) reductase inhibitors. Since lovastatin came out, simvastatin, pravastatin, fluvastatin and atorvastatin have been used in clinic successively, occupying an extremely important position in lowering blood lipids. Atorvastatin calcium (Lipitor) has been the world's top selling drug since 2000.

Due to the impact of patent expiration, the global market sales volume in 2009 was 12.3 billion dollars, down from 13.288 billion dollars in 2008. Nevertheless, as the only drug with annual sales of more than 10 billion dollars for many years in a row, as the patent is about to expire, the optimization of the new synthesis process has once again attracted the attention of scientists.

Atorvastatin Calcium Drug interaction:

1. The risk of myalgia increases when it is combined with cyclosporine, bethoids, erythromycin, niacin and pyrrole antifungal drugs.

2. When combined with antacids such as MaaloxTc suspension (containing aluminium hydroxide and magnesium hydroxide), blood concentration of this product can be reduced by 30%, but the effect of lowering LDL-C is not changed.

3. When used in combination with digoxin, the steady-state blood concentration of digoxin increased by about 20% after multiple administration.

4. When combined with erythromycin (cytochrome P4503A4 inhibitor), the blood concentration of this product increases by about 40%.

5. Combined with oral contraceptives Norethisterone or ethinynoestradiol, the area under the concentration-time curve (AUC) of Norethisterone and ethinynoestradiol increased by 30% and 20%, respectively.

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