Beta-Nicotinamide Adenine Dinucleotide CAS 53-84-9 Pharma Powder Raw Materials

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Beta-Nicotinamide Adenine Powder Usage and Synthesis.

Beta-Nicotinamide Adenine Dinucleotide is involved in various physiological activities such as cellular substance metabolism, energy synthesis and In a healthy state, the concentration of Beta-Nicotinamide Adenine Dinucleotide in the human body Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate nucleotide (abbreviated as DPN), or Co-Dehydrogenase I or Coenzyme I. NAD Powder has a protective effect against ischemic surgery-induced renal infarction. NAD Powder has a protective effect against ischemic-surgery-induced renal infarction.

Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate nucleotide (abbreviated as DPN), or Co-Dehydrogenase I or Coenzyme I. In mammals, there are two states, oxidized (NAD+) and reduced (NADH). The oxidized (NAD+) has the maximum UV absorption spectrum at 260 nm, and through various deaminases, accepts a hydrogen atom and an electron from the substrate to become reduced (NADH), which has the maximum absorption at 340 nm.

Beta-nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of the ADP ribose fraction in ADP ribosylation reactions, and as a precursor to the second messenger molecule cyclic ADP ribose. beta-Nicotinamide adenine dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.

Application/Function of Beta-Nicotinamide Adenine Powder.

Nicotinamide adenine dinucleotide is a white powder that absorbs moisture readily and is acidic in aqueous solution. The solid is stable under dry conditions, and the neutral or weakly acidic aqueous solution of this product can be stored at room temperature for 7 days, accelerated deterioration and decomposition when exposed to alkali and heat. Specific rotation degree [α] 23D-34.8° (1%, water); its aqueous solution has maximum absorption at 260nm and 340nm. Freely soluble in water, insoluble in organic solvents such as acetone.

Nicotinamide adenine dinucleotide is a coenzyme drug. It is mainly used clinically as an adjuvant treatment for coronary heart disease, and can improve symptoms such as chest tightness and angina pectoris. Adverse reactions occasionally include dry mouth, dizziness and nausea.

Beta-Nicotinamide Adenine Powder is an essential coenzyme in living organisms and is used in biochemical studies, clinical diagnostics, clinical drug and pharmaceutical research.

Nicotinamide adenine dinucleotide is involved in energy metabolism and substance metabolism in the body, and facilitates cell repair and renewal. It is used in the treatment of coronary heart disease, myocarditis, leukopenia and other conditions.

Nicotinamide adenine dinucleotide is a coenzyme that transports protons (more precisely hydrogen ions), which appear in many metabolic reactions of the cell. nADH or more precisely NADH+H+ is its reduced form. It can be reduced carrying up to two protons (written as NADH+H+). NAD+ is a coenzyme of dehydrogenases, such as ethanol dehydrogenase (ADH), used for the oxidation of ethanol. It plays an irreplaceable role in glycolysis, gluconeogenesis, tricarboxylic acid cycle and respiratory chain. The intermediate product will deliver the hydrogen shed to NAD to make NADH+H+. In turn, NADH+H+ acts as a carrier of hydrogen and synthesizes ATP in the respiratory chain by means of chemo-osmotic coupling.

Mechanism of action of Beta-Nicotinamide Adenine Powder:

Nicotinamide adenine dinucleotide is involved in a variety of physiological activities such as cellular substance metabolism, energy synthesis, cellular DNA repair, and has an important role in the immune capacity of the body. In a healthy state, the concentration of nicotinamide adenine dinucleotide in the body is stable and maintains the normal function of all cells. The concentration of nicotinamide adenine dinucleotide in the body determines the process and degree of cellular aging, and a decrease in concentration accelerates the process of cellular aging. Studies have shown that NAD+ has a protective effect on renal infarction caused by ischemic surgery and can significantly reduce serum levels of urea nitrogen and creatinine; NAD+ has a protective effect on renal tubular injury caused by ischemic surgery.

NAD+ (Nicotinamide adenine dinucleotide, NAD+ for short) can effectively protect renal ischemia-induced renal injury, and NAD+ has important application value in the preparation of drugs against renal ischemic injury. In addition, nicotinamide adenine dinucleotide has some applications in the preparation of drugs for the treatment of inflammatory pain. NAD+ is involved in the regulation of inflammatory pain induced by formalin and complete Freund's adjuvant (CFA) through the NAD+-dependent deacetylases SIRT1 and SIRT2, while SIRT1 and SIRT2 are involved in the inhibitory effect of NAD+ on inflammatory pain through different mechanisms, thus achieving an inflammatory pain with analgesic effects.

Production method of Beta-Nicotinamide Adenine Powder:

CN201511022464.3 presents a method for the preparation of nicotinamide adenine dinucleotide, comprising the steps of:

• S1, crushing cells: soaking yeast cells in aqueous hydrochloric acid solution for 0.5-2.5h, performing temperature difference wall-breaking treatment, filtering with ceramic membrane, and taking the filtrate to obtain clear liquid A;
• S2, Concentration: Take the clear solution A obtained in S1 and ultrafiltrate it, take the ultrafiltrate and nanofiltrate it to get the concentrated solution B. Adjust the pH of concentrated solution B with aqueous hydrochloric acid solution = 2-2.5 to get concentrated solution C;
• S3, elution: pass Concentrate C obtained in S2 through D152 resin column, elute with ammonia, collect Eluate D, adjust pH = 7-8 of Eluate D with aqueous hydrochloric acid solution, pass through 717 resin column, elute with aqueous potassium chloride solution, and collect to obtain Comprehensive Liquid E;
• S4, separation: Nanofiltration of the synthesis solution E obtained in S3 to obtain the concentrate F; adjust the pH of the concentrate F with aqueous nitric acid solution = 1-3, add acetone to precipitate, and centrifuge to obtain the solid G;
• S5, purification: dissolve solid G obtained in S4 with water, pass preparative chromatography, desalinate, separate, collect the isolate, concentrate, and lyophilize to obtain nicotinamide adenine dinucleotide.

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