Lidocaine Hydrochloride Raw material powder Lidocaine Hcl

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Lidocaine Hydrochloride Powder Usage and Synthesis.

Lidoca hydrochloride is a local anesthetic agent of medium effect amide. Used as a local anesthetic and antiarrhythmic drug. Mainly used for:

(1) Infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve block.

(2) Treatment of premature ventricular beats and ventricular tachycardia after acute myocardial infarction (AMI), as well as digitalis poisoning, cardiac surgery, cardiac catheterization caused by ventricular arrhythmias, but usually ineffective for supraventricular arrhythmias.

Uses of Lidocaine Hydrochloride.

Lidocaine hydrochloride has the characteristics of strong penetration, strong dispersion, quick effect, anesthetic efficacy is twice that of procaine, and toxicity is 1. The anesthetic effect can appear 5 minutes after administration, and the anesthetic effect can last 1 to 1.5 hours, 50% longer than procaine. After absorption, it can inhibit the central nervous system, inhibit ventricular automaticity, shorten the refractory period, and can be used to control ventricular tachycardia and treat arrhythmia symptoms such as premature ventricular beat, ventricular tachycardia and ventricular fibrillation. It is effective for heart disease or arrhythmia caused by cardiac glycosides, but not effective for supraventricular tachycardia. This product acts quickly, has a short duration, is ineffective orally, and is often administered intravenously.

Lidocarzine hydrochloride local anesthetics. After blood absorption or intravenous administration, the drug has obvious biphasic effect of excitatory and inhibitory on the central nervous system, and there can be no precursor excitement, analgesia and lethargy, and the pain threshold is increased when the blood concentration is low. As the dose increases, the effect or toxicity increases, and the subtoxic blood concentration has anticonvulsant effect.

Drug interaction of Lidocaine Hydrochloride.

(1) Cimetidine and beta-blockers can inhibit lidocaine metabolism by the liver, increase its blood concentration, and cause adverse reactions in the heart and nervous system, so the dose of lidocaine hydrochloride should be adjusted.

(2) Barbiturates can promote the metabolism of lidocaine hydrochloride, and the combination of the two drugs can cause bradycardia and sinus arrest.

(3) Combined with procainamine, can produce transient delirium and hallucination, but does not affect the blood concentration of this product.

(4) Isopropyl epinephrine can increase the total clearance rate of this product due to increased liver blood flow; The total clearance rate of lidocaine hydrochloride decreased because norepinephrine reduced hepatic blood flow.

(5) Incompatibility with the following drugs: phenobarbital, sodium thiopental, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine.

Product Method of Bulk Lidocaine Hydrochloride Powder.

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