Tianeptine sodium salt Raw Materials powder

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Tianeptine sodium salt powder Usage and Synthesis.

Tianeptine sodium salt is used for the treatment of mild, moderate or severe depression, neurogenic and reactive depression, anxiety depression in the physical, especially gastrointestinal discomfort, and anxiety depression in alcohol-dependent patients during withdrawal. The recommended dose is 12.5mg tid taken orally before morning, middle and evening main meals. Chronic alcoholics, whether or not they have cirrhosis, do not need to adjust the dose. In patients over 70 years of age and with renal dysfunction, the dose is limited to 2 tablets daily.

Uses of Tianeptine sodium salt powder.

1. Antidepressants

Tineptine increases serotonin and norepinephrine levels by regulating neurotransmitter balance, relieving low mood and slow thinking.

2. Anti-anxiety

The drug can increase inhibitory synaptic transmission mediated by GABA receptors in the brain and reduce excitability of the central nervous system, thereby reducing anxiety symptoms.

3. Improve cognitive function

Tianeptine can promote the functional recovery of cholinergic neurons, improve the synthesis and release of acetylcholine, and improve memory, learning and other cognitive functions.

4. Improve your memory

Tianeptine can increase the sensitivity of the postsynaptic membrane to acetylcholine, enhance the transmission of nerve impulses, and contribute to the memory and storage of information.

5. Improve your focus

The drug has a certain central nervous system activity, can enhance the excitability of the cerebral cortex, make the individual more sensitive to external stimuli, thus improving attention.

Possible side effects, such as nausea, vomiting, insomnia, etc. should be monitored when using Tianeptine, and timely feedback should be reported to the doctor. Elderly patients or those with cardiovascular disease should be used with caution to avoid potential risks.

Pharmacological action of Tianeptine sodium salt powder.

Tianeptine sodium is a tricyclic antidepressant, and its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic gap, and may improve the transmission of 5-HT neurons. No affinity for choline or adrenergic receptors. Antidepressant efficacy is similar to tricyclic, but the tolerance is better than tricyclic. In animal experiments, it can increase the spontaneous activity of hippocampal pyramidal cells and accelerate the recovery of their function after inhibition. It can increase the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus. The absorption of tineptine sodium in the digestive tract is rapid and complete. Rapid distribution, PPB up to 94%. It is completely metabolized in the liver by β-oxidation and N-demethylation, clearance of terminal T1/2 is short, 2.5 h, and a very small amount of the drug (8%) is excreted from the kidney, mainly its metabolites from the urine. Patients with renal insufficiency cleared T1/2 for 1h.

Preparation method of Bulk Tianeptine sodium salt powder.

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