Skin medicine Tazarotene raw Powder

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Tazarotene Usage and Synthesis.

tazarotene gel, a topical formic acid preparation, can be used to treat psoriasis. Early studies have shown that topical application twice daily for eight weeks in approximately 50% of patients with mild to moderate psoriasis results in relief of at least 75% of skin lesions. However, the total elimination of plaque was less than 10%. tazarotene gel is available in 0.05% and 0.1% concentrations. 0.1% gel for topical use once a day and twice a day makes no difference. However, 0.5% gel is less effective when used externally once a day.

Tazarotene is a synthetic ethylene retinal, which is rapidly converted to tazarotene acid after topical administration and exerts pharmacological effects. The binding of tazarotenic acid to retinuronic acid receptor gamma (RAR-γ) in the skin may improve clinical symptoms by restoring normal skin differentiation and reducing skin inflammation.

Uses of Tazarotene.

Tazarotene can relieve symptoms such as rashes, papules and pustules caused by acne vulgaris. It can also be used to relieve symptoms of skin lesions such as itching and desquamation caused by psoriasis

Tazarotene is a dermatological drug that can restore normal skin differentiation and reduce skin inflammation. It is mainly used for topical treatment of psoriasis and acne. It has the function of epidermal cell differentiation and proliferation, as well as reducing inflammation.

Tazarotene is indicated for topical treatment of plaque psoriasis vulgaris and acne vulgaris. However, note that this product is not suitable for acute eczema skin diseases, please consult a doctor before use.

In vitro study of Tazarotene.

In HL-60 human myeloid leukemia cells, Tazarotene causes ERK activation, RB tumor suppressor protein phosphorylation, G0 block, and myeloid differentiation. Tazarotene is able to drive the early or late part of the period leading to differentiation or G0 arrest, and is interchangeable with the Raralpha-selective ligand. By interacting with specific nuclear retinoic acid receptors (RARs), Tazarotene therapeutically regulates gene transcription, thereby regulating three important causative factors in psoriasis. Tazarotene inhibits proliferation of fibroblasts and synthesis of DNA and collagen. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. tazarotene also upregulates three new genes, TIG-1 (Tazarotene-inducible gene-1), TIG-2, and TIG-3, which may mediate anti-proliferative effects. In retinoid responsive breast cancer cell lines, Tazarotene causes growth inhibition by upregulation of TIG3.

Product Method of Tazarotene.

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