Betahistine dihydrochloride raw Powder

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Betahistine dihydrochloride Usage and Synthesis.

Betahistine hydrochloride is mainly used for Meniere's syndrome, vascular headache and cerebral arteriosclerosis, and can be used to treat acute ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral embolism, transient cerebral insufficiency, etc. It is also effective for orthostatic vertigo and tinnitus caused by hypertension.

Uses of Betahistine dihydrochloride.

Betahistine hydrochloride, also known as antidazzline and petadine, is a histamine H1 receptor agonist and belongs to histamine vasodilator drugs. It can dilate capillaries, improve microcirculation, increase cerebral blood flow and inner ear blood flow, relax the inner ear precapillary sphincter, and eliminate inner ear vertigo, tinnitus and ear block. It is mainly used to treat Meniere disease (an idiopathic inner ear disease), acute and chronic ischemic cerebrovascular disease, and is also used to treat cerebral arteriosclerosis, ischemic cerebrovascular disease, head trauma or hypertension caused by upright vertigo, dizziness, tinnitus, deafness, inner ear vertigo, etc., which has a alleviating effect on various causes of headache and has obvious effect on bedsore.

The effect of betahistine hydrochloride on capillary dilation is similar to that of histamine, but it does not increase its permeability, can significantly increase the blood flow of the brain and inner ear, eliminate endlymphedema, and directly inhibit the large number of impulses generated by the multitouch type I neurons of vestibular nucleus, thus eliminating the symptoms of Meniere syndrome such as vertigo, tinnitus and ear closure. The drug also has mild anticoagulation, antiplatelet aggregation, reduced blood viscosity and diuretic effects.

Pharmacological action of Betahistine dihydrochloride

Betahistine hydrochloride has a significant dilating effect on cerebrovascular and cardiovascular systems, especially on the vertebral base artery system, which significantly increases the blood flow of the heart, brain and surrounding circulation, improves blood circulation, and reduces systemic blood pressure. In addition, it can increase the blood flow of the cochlea and vestibule, thereby eliminating internal ear vertigo, tinnitus and ear closure, increase capillary permeability, and promote extracellular fluid absorption. Elimination of lymphoid edema; It can counter the vasoconstriction effect of catecholamines and reduce arterial pressure, inhibit plasma coagulation and ADP-induced platelet agglutination, prolong the time of thrombosis in vitro in rats, and have slight diuretic effect.

Extraction method of Betahistine dihydrochloride.

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