Supplement l ergothioneine Food Grade Pure 99% l-ergothioneine powder

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l-ergothioneine powder of Usage and Synthesis.

Ergothionein has a wide range of applications and market prospects in organ transplantation, cell preservation, medicine, food and beverage, functional food, animal feed, cosmetics and biotechnology. It is also a highly protective, non-toxic natural antioxidant for cells and is not easily oxidized in water, which allows their concentration in some tissues to reach mmol and activates the natural antioxidant defense system of cells. Among the many antioxidants, ergothione is particularly unique because it can chelate heavy metal ions, which can prevent the body's red blood cells from being damaged by free radicals.

l-ergothioneine food has strong antioxidant activity: scavenging reactive oxygen species, chelating divalent metal ions, activating antioxidant enzymes, inhibiting superoxide dismutase, and inhibiting oxidative reactions of various hemoglobin proteins. Due to these properties of ergothioneine, it has a wide range of applications and market prospects in the fields of medicine, food and beverage, functional food, animal feed, cosmetics and biotechnology.

Uses of l-ergothioneine.

• L-ergothioneine is a natural molecule isolated from the rye ergot fungus and later found in rat red blood cells and liver, as well as many other animal tissues. Its antioxidant properties could provide the therapeutic potential of the compound, or it could be used as a food additive or cosmetic.
• Ergothionein is a powerful hypochlorous acid scavenger (HOCl), and while many compounds can react with hypochlorous acid, few react as quickly as ergothionein. a1- antiprotease inhibitors (apis), such as elastase, are particularly sensitive to hypochlorous acid, and physiological concentrations of ergothione are very effective in protecting apis against hypochlorous acid-induced inactivation, since neutrophils are the main source of hypochlorous acid in the body. One of its roles is to protect red blood cells from neutrophils that come from sites of normal function or pathological inflammation.

Function of action l-ergothioneine.

• Antioxidant effect

• Ergothioneine is a natural amino acid derived from plants and can be accumulated in animals, research has proved that it has the role of antioxidant, it can effectively scavenge -OH, can chelate divalent iron ions and copper ions, preventing the formation of -OH by H2O2 in the presence of iron or copper ions, also inhibit the copper ion-dependent oxidation of oxyhaemoglobin also inhibit the peroxidation of arachidonic acid in the myoglobin (or haemoglobin) mixed with H2O2, which promotes the reaction of arachidonic acid in the presence of H2O2. ) peroxidation of arachidonic acid prompted by mixing with H2O2.
• Ergothioneine is also a potent scavenger of hypochlorous acid, which prevents the inactivation of a 1-antiprotease. However, it does not inhibit the peroxidation of lipid particles in the presence of iron ions.AKanmu D et al. have shown that ergothioneine present in the body at certain concentrations can act as an antioxidant.

• Protective effects on cells

• Ergothioneine is a powerful hypochlorite scavenger (HOCl), and while many compounds react with hypochlorite, few do so as rapidly as ergothioneine.
• a 1-Antiprotease inhibitors (APIs), such as elastase, are particularly sensitive to hypochlorite, and physiological concentrations of ergothioneine are very effective in protecting APIs against the inactivation triggered by hypochlorite. Since neutrophils are the main source of hypochlorite in the body, one of the effects of ergothioneine is to protect red blood cells from neutrophils from either normally functioning or pathologically inflamed sites.

• Anti-inflammatory effects

• Peroxynitrite, formed endogenously by the limited diffusion reaction of NO and superoxide, is a potent oxidizing agent associated with the pathophysiology of inflammatory conditions such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia and sepsis.
• l-ergothioneine supplement inhibits peroxynitrite anion-mediated oxidation of amino acids, such as complexine nitration, thus providing therapeutic feasibility for inflammation.

Route of intake and safety of l-ergothioneine supplement.

• Dietary supplement: Approximately 1-5 mg of ergothioneine can be obtained by consuming 50-100 g of mushrooms per day.
• Supplements: Commercially available in capsule or powder form, with attention to dosage (usually no more than 30 mg per day is recommended).
• Safety: Current studies show minimal toxicity, but overdose may cause mild gastrointestinal distress. Use with caution in pregnant and lactating women.

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