Clavulanate Potassium Powder CAS 61177-45-5 Raw Material

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Clavulanate Potassium Powder Usage and Synthesis.

Clavulanate Potassium Powder is an enzyme-inhibiting β-lactam antibiotic obtained from rod streptomycin culture, which has only weak antibacterial activity and is mostly worthless alone, but can firmly bind to most β-lactam-enzymes to produce irreversible conjugates to inhibit the destruction of antibiotic antibacterial properties by β-lactam enzymes and increase the antibacterial spectrum and efficacy of certain antibiotics. Clavulanate Potassium Raw Material is used in combination with semi-synthetic penicillins to treat peripheral infections caused by Escherichia coli, Aspergillus, Bacillus cereus, H. influenzae, S. pneumoniae, etc. Clavulanate Potassium CAS 61177-45-5 is a β-lactamase inhibitor. lactamase inhibitor.

Clavulanate Potassium is a new type of β-lactam antibiotic produced by Streptomyces rods, also known as potassium rods. It is a white or slightly yellow crystalline powder, slightly odorous and very easy to induce wetness. Very soluble in water, soluble in methanol, slightly soluble in ethanol, insoluble in ether. pH value of 1% aqueous solution is 6.0~8.0.

Application/Function of Clavulanate Potassium Powder.

Potassium clavulanate is a β-lactam antibiotic with enzyme inhibition obtained from rod streptomycin culture, which has only weak antibacterial activity and is mostly worthless alone, but can bind firmly to most β-lactam-enzymes to generate irreversible conjugates to inhibit the destruction of antibiotic antibacterial properties by β-lactamases and increase the antibacterial spectrum and efficacy of certain antibiotics. It is an effective β-lactamase inhibitor because of its broad-spectrum inhibition effect, not only on the enzyme of staphylococci, but also on the β-lactamase produced by most G- bacteria. It is often used in combination with penicillins to overcome bacterial resistance and improve the efficacy. Such as amoxicillin-potassium clavulanate tablets, ticarcillin-potassium clavulanate injection, etc.

Pharmacological Effects of Clavulanate Potassium Powder

Potassium clavulanate binds strongly to a variety of beta-lactamases, producing irreversible conjugates. It can act on specific sites on the cell membrane and has weak antibacterial activity. Potassium clavulanate is an enzyme inhibitor with a broad spectrum of enzyme inhibition, strong enzyme inhibition, and good cell membrane permeability. It has a strong inhibitory effect on almost all β-lactamases, including penicillinase, broad-spectrum enzymes and ultra-broad-spectrum enzymes that can inactivate third-generation cephalosporins, especially for plasmid-mediated β-lactamases, the enzyme inhibitory effect of this product is significantly better than that of sulbactam, but for chromosomal-mediated β-lactamases this product is inferior to sulbactam.

It is often used in combination with penicillins, which can not only improve the antibacterial activity against common enzyme-producing resistant Gram-positive and negative bacteria, but also improve the antibacterial activity against some pathogenic bacteria originally insensitive to penicillins, such as anaerobic bacteria and Pseudomonas aeruginosa, and have better synergistic therapeutic effects on certain deep tissue infections such as lung infections, abdominal infections and bone and joint infections. Clavulanic acid is stable in gastric acid when administered internally and is easily absorbed and unaffected by food. Peak blood concentrations appear 1 to 2 h after internal administration in monogastric animals. It is widely distributed in the body and can rapidly penetrate into body fluids and most tissues. The drug concentration in the thoraco-abdominal fluid can exceed 50% of the plasma concentration, and the effective therapeutic concentration can be reached in the bile, middle ear and tonsil, but the concentration in the cerebrospinal fluid increases when meningitis occurs.

Rational Compounding of Clavulanate Potassium Powder

• 1, Clavulanic acid potassium combined with penicillins and cephalosporins, the antibacterial efficacy against enzyme-producing bacteria is significantly enhanced.
• 2, Combined application with ticarcillin has stronger effect on Enterobacteriaceae and Pseudomonas aeruginosa, but not for ticarcillin-resistant Pseudomonas spp. and Enterobacter spp. infections.
• 3、Clavulanic acid can improve the antibacterial effect of amoxicillin on β-lactamase producing bacteria such as Klebsiella spp. and Aspergillus spp. by 4 to 32 times, and the antibacterial activity of Haemophilus influenzae by 32 times.
• 4、The product is not effective when applied alone. It is often used in combination with penicillins such as amoxicillin for enzyme-producing and non-enzyme-producing Staphylococcus aureus, Staphylococcus, Streptococcus, Escherichia coli, Pasteurella and other infections of skin and soft tissues in dogs and cats; it is also used for respiratory tract, gastrointestinal tract and urinary tract infections in pigs and poultry caused by sensitive bacteria; it has also achieved good efficacy in the treatment of typhoid fever and paratyphoid fever.

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