Pharmaceutical Diosmin Raw Materials Powder CAS 69-09-0 API Factory Supply

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Diosmin Powder Usage and Synthesis.

Diosmin Powder, also known as Avellan, is a medication for the treatment of various symptoms associated with acute attacks of haemorrhoids.

Diosmin Raw Materials is also used for the treatment of various symptoms associated with veno-lymphatic insufficiency (heaviness of the legs, pain, and morning soreness and discomfort). 

As one of the commonly used vasoprotective drugs in clinical practice, Diosmin is commonly used in the treatment of various peripheral vascular diseases, and the results of clinical studies have shown that Diosmin can improve the circulation of blood and lymphatic fluids, and reduce oedema.Diosmin CAS 69-09-0 is used in food, pharmaceuticals, and health care products. A flavonoid found in citrus fruits and an agonist of the aryl hydrocarbon receptor (AhR).

Uses and functions of Diosmin Powder.

• 1, varicose veins of the lower limbs: clinical research shows that Diosmin can effectively improve the clinical symptoms of patients with varicose veins of the lower limbs, reduce pain, activity inconvenience, relieve venous stasis in the lower limbs, improve venous return.
• 2, acute or chronic haemorrhoids: clinical studies have shown that for patients with chronic haemorrhoids, Diosmin can effectively improve the size of their haemorrhoids, reduce the number of bleeding and anal prolapse, and effectively prevent and treat their acute attacks; secondly, for patients with acute haemorrhoidal attacks, the application of Diosmin on the basis of haemostatic and other symptomatic treatments can quickly control bleeding and reduce perianal pain, thus effectively alleviating the patient's pain and improving the prognosis. Improve the prognosis.
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• 3, Lymphatic reflux disorder, lymphoedema: Diosmin can effectively improve lymphatic reflux and reduce limb swelling. Clinical studies have shown that after taking Diosmin, patients with lymphoedema have a significant reduction in swelling and pain in the limbs, which makes the lymphatic circulation smooth and improves the quality of life and health of the patients.
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• 4, peripheral skin ulcers: clinical studies have shown that on the basis of promoting skin healing treatment, with the use of Diosmin, can effectively accelerate the prognosis of skin wounds or ulcers, reduce the local inflammatory response, alleviate skin pain, thereby effectively improving the prognosis of the disease.

Pharmacological Effects of Diosmin Powder.

• 1、It has specific affinity to venous system and enhances the tension of veins without affecting the arterial system;
• 2、It can reduce the viscosity of blood in microcirculation system and improve the flow rate to reduce stagnation;
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• 3、It can enhance the contraction of lymphatic vessels and the speed of lymphatic drainage in the lymphatic system, and accelerate the reflux to reduce oedema.
• 4、The commercially available Diosmin adopts micronisation technology, which increases the contact area after the use of the drug, more absorption and higher bioavailability. It is suitable for all kinds of haemorrhoids and acute episodes of haemorrhoids, and can also treat chronic venous insufficiency, such as varicose veins, lower limb ulcers and so on.

Production method of Diosmin Powder.

Currently, Diosmin is mainly semi-synthesised from hesperidin extracted from natural plants.

Chinese Patent CN104250276-A announces an industrial production of Diosmin. The specific steps are as follows: adding hesperidin (glycoside) to a mixed solvent of pyridine and dimethylsulfoxide, and then adding potassium iodide and sulfuric acid to carry out a dehydrogenation reaction to obtain a reaction intermediate product;

To the reaction intermediate product add methanol solution containing sodium hydroxide for reaction; then add acid to adjust the pH value, static precipitation of crystals, to get Diosmin. The purity of Diosmin produced by this method is generally lower than 95%, which is not suitable for sale as a drug and needs further separation and purification.

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