Pharmaceutical Dopamine Hydrochloride Raw Materials Powder CAS 62-31-7 API Factory Supply

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Dopamine Hydrochloride is one of the most important catecholamines that plays a key role in the central nervous system and renal system. Dysregulation of dopamine secretion in the body will lead to heart disease, schizophrenia and Parkinson's disease, etc. 

Dopamine Hydrochloride Powder has good water solubility, enhances myocardial contraction, increases blood output, and is used in large quantities for shock syndromes caused by myocardial infarction, trauma, endotoxin sepsis, cardiac surgery, renal failure, congestive heart failure, etc. 

Dopamine Hydrochloride Raw Materials is a blood pressure raising drug and a biochemical reagent.

Uses and functions of Dopamine Hydrochloride Powder.

Dobutamine hydrochloride can be used for various types of shock and hypotension. Including toxic shock, cardiogenic shock, haemorrhagic shock, central shock, especially for patients with renal insufficiency, reduced cardiac output, increased peripheral vascular resistance and who have been replenished with sufficient blood volume. It can also treat cardiac insufficiency and acute renal insufficiency.

Pharmacological Effects of Dopamine Hydrochloride Powder.

This product is the precursor of synthetic adrenaline in the body, with β (mainly β1 receptor) receptor agonism, but also α receptor agonism, but also to promote the release of norepinephrine. It enhances myocardial contractility, increases cardiac output, and accelerates heart rate to a lesser extent (not as pronounced as isoprenaline);

excitation of alpha receptors in blood vessels of tissues such as skin and muscle leads to vasoconstriction and a decrease in blood supply;

excitation of dopamine receptors in blood vessels of the viscera (kidneys, mesentery, and heart) leads to dilation and an increase in blood flow. The change in total peripheral resistance is not significant, but favours the improvement of blood supply to vital organs in shock.

Production method of Dopamine Hydrochloride Powder.

It is obtained by ring opening of piperyleneamine. Piperonyl ethylamine and phenol were added to the reaction pot, cooled, hydrochloric acid was added slowly, and the temperature was raised to 110°C and refluxed for 12-44 h. After the reaction reached the end point, it was slightly cooled, and water was added and stirred well. Leave to stratify and separate the phenol layer. 

The aqueous layer was extracted with isopropyl acetate, the extracted aqueous layer was evaporated to dryness under reduced pressure (8.0kPa), then 1/2 amount of ethanol and hydrochloric acid were added and heated to dissolve. 

Cooling, crystallisation, filtration, filter cake washed with ethanol, drying, to get the finished product. Yield 74%.

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