Eseroline Powder Raw Material

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Eseroline Powder Usage and Synthesis:

Eseroline is a smooth muscle and transverse muscle excitatory agent, a reversible cholinesterase inhibitor, which acts on M-cholinergic receptors and exhibits similar effects to cholinergic drugs.

It can be used for the relief of tricyclic antidepressants and benzodiazepine overdose, and a potent antagonist of anticholinergic poisoning such as atropine.

The drug is easily absorbed by oral administration, injection, and local mucosal administration, and can cross the blood-cerebrospinal fluid barrier.

Eseroline is a very toxic chemical, also known as cuprous oxide.

Eseroline Powder is a black or brown powdered solid. Eseroline CAS 469-22-7 Raw Powder is highly oxidizing and corrosive,

Eseroline Powder is highly oxidizing and corrosive, irritating to the skin, eyes, and respiratory tract, and can cause serious injury or even be fatal when inhaled or touched.

Therefore, oxidized toxic lentil base should be stored and used properly to avoid contact and inhalation.

Pharmacokinetics of Eseroline Powder:

Commonly used as salicylate, it is colorless or light yellow shiny needle crystal, odorless, slightly soluble in water (1:75), soluble in alcohol. It is slightly soluble in water (1:75) and soluble in alcohol. When exposed to sunlight or air, oxidation gradually turns red, which means it is not suitable for use. Its solution is also easy to turn red, heating or due to the alkalinity of the glass container can accelerate its change, so the solution should not be stored for a long time, the container is best to be washed with 1% hydrochloric acid first. If the solution has changed slightly, it is slightly red, it can still be used; if the color has been dark, it is not suitable for use. Adding 3% boric acid or 0.1% sodium bisulfite or 0.1% disodium edetate can delay the discoloration.

Clinical Application of Eseroline Powder:

Eseroline is an alkaloid extracted from the seeds of phsostigmavenenosum, an African species, which has been synthesized artificially.

It is a tertiary amine compound. It is readily absorbed through mucous membranes. It is easily absorbed orally and by injection, and also easily crosses the blood-cerebrospinal fluid barrier.

It has similar reversible cholinesterase inhibiting effect as neostigmine, and has excitatory effect on central nervous system in small dose and inhibitory effect in large dose. Containing 0.25%~0.5% salicylate,

it has the effect of pupil reduction and lowering IOP and contraction of ciliary muscle causing regulatory spasm, etc.

The pupil reduction can be maintained for 1~2 days after 5min of eye drop, and the regulatory spasm disappears quickly.

The effect is stronger and longer lasting than that of brassinolide, but it is more irritating and its alternate use can enhance the pupil reduction effect.

Some people advocate that, in the beginning of 0.5h, 4 to 5 drops of toxic lentil, and then switch to bradykinin, the pupil reduction effect is better.

Toxic lentil is an inhibitor of tertiary amine cholinesterase activity. It is similar to brassinolide. It is more toxic.

Toxic lentil base can be rapidly absorbed by gastrointestinal, subcutaneous tissue and mucous membrane, and can be destroyed by cholinesterase hydrolysis (destroyed within 2h after subcutaneous injection of 1mg).

It can cross the blood-cerebrospinal fluid barrier. Rarely excreted in urine. Pupil constricting effect can be seen about 10 min after eye drops, and can maintain IOP reduction for 1 to 2 days. It is rarely used systemically because of poor selectivity.

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