Ergosterol Raw Materials Ergosterol Powder

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Ergosterol Powder Usage and Synthesis.

Ergosterol is an important sterol found in fungi and some plants.

It is an important component of fungal cell membranes and plays an important role in ensuring the integrity of cell membranes, the activity of membrane-bound enzymes, membrane fluidity, cell viability, and the transport of cellular substances. Ergosterol is also a precursor for the production of vitamin D2 and an intermediate in the production of hormone drugs, which can be used to produce cortisone.

Ergosterol appears as a colourless bright leafy crystal or white crystalline powder with no specific odour, soluble in trichloromethane, ethanol, ether and benzene and insoluble in water. Ergosterol has the advantages of antibacterial, antioxidant, low temperature resistance, etc., and has a broad application prospect in the fields of medicine and pesticide.

The preparation methods of ergosterol include biosynthesis and chemical synthesis.

DXNT's platform adopts high performance liquid chromatography (HPLC) equipped with evaporative light scattering detector or diode array detector, which can efficiently and accurately realise the detection of ergosterol content in samples.

Uses of Ergosterol.

Ergosterol is a biological precursor of vitamin D2 and is found in the cell membranes of fungi and some protozoa such as trypanosomes. Ergosterol is used in functional studies of antifungal drugs such as amphotericin B and its analogues, and in studies of the ergosterol biosynthetic pathway in various fungi.

Chemical Properties of Ergosterol.

Colourless needle-like or flaky crystals. Soluble in ethanol, ether, benzene and trichloromethane, insoluble in water. Vitamin D is prepared by dissolving ergosterol in solvents such as chloroform, ether or cyclohexane, adding it to a flask of quartz glass and irradiating it with ultraviolet light.

Product Method of Bulk Ergosterol Powder.

Yeast as raw material

Preparation of paste take dry yeast powder through 60-80 mesh sieve, add 3 times the amount of 82%-84% ethanol extraction 18-24h, at 70 ℃ insulation 3h, constant stirring, cooling to 30 ℃ filtration, filtering, filtrate residue and then extracted 2 times, dumping ethanol, combined with the extract solution, 70 ℃ vacuum concentration, concentration time does not exceed 24h, to get the paste. The filtrate was used to extract ribonucleic acid and yeast polysaccharide.

Dry yeast or white earth mould [ethanol] → [first 68-70 ° C, after 30 ° C or less] extract [70 ° C concentration] → paste ergosterol crude preparation take the paste with 5% -10% of water, add 3-5 times the amount of ether, stirring vigorously for 2-3h, static 16-20h, discard the middle and lower layers of the liquid, the upper layer of ether liquid in the refrigerator at -5 ° C placed in the 20-24h, the precipitation of ergosterol crystals.

Paste [ether] → upper ether solution [-5 ℃] → [20-24h] ergosterol crude.

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