Clotrimazole Raw Materials powder Clotrimazole

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Clotrimazole powder Usage and Synthesis.

Clotrimazole has a broad-spectrum antifungal activity, and has good antibacterial effects on Epidermophyton, Trichophyton, Aspergillus, Chromatid fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, Blastomyces dermatitidis, Coccidioides immitis, Histoplasma, etc.

Mechanism of Clotrimazole powder.

(1) By reducing the activity of cytochrome P450, it inhibits the biosynthesis of ergosterol and other sterols in the fungal cell membrane, damages the fungal cell membrane and changes its permeability, causing the leakage of important substances in the cell.

(2) Clotrimazole can also inhibit the biosynthesis of triglycerides and phospholipids in fungi.

(3) It can also inhibit the activity of oxidases and peroxidases, leading to excessive accumulation of hydrogen peroxide in cells, causing degeneration of fungal subcellular structures and cell necrosis.

(4) For Candida albicans, it can inhibit the process of its transformation from spores to invasive hyphae.

Medicine interactions of Clotrimazole powder.

Clotrimazole can inhibit the metabolism of drugs such as sirolimus and dofetilide mediated by cytochrome P4503A4, thereby increasing the blood concentrations of these drugs; when used in combination with tacrolimus, trimetrexate, etc., it can slow down the metabolism of these drugs and increase their toxic reactions; when clotrimazole is used in combination with betamethasone, it can make the skin susceptible to infection or increase the chance of microbial reproduction, and the possible mechanism is that the local inflammatory response is inhibited; when used in combination with nystatin, amphotericin B and flucytosine, it has no synergistic antibacterial effect on Candida albicans; and when used in combination with amphotericin B, it has an antagonistic effect in pharmacodynamics.

Product Method of Bulk Clotrimazole powder.

It is obtained by esterification, addition, hydrolysis, chlorination and condensation of o-chlorobenzoic acid. It can also be obtained by chlorination of o-chlorotoluene to obtain o-chlorotrichlorotoluene, which is then condensed with benzene in the presence of aluminum chloride to produce diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.

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