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Sinomenine Hydrochloride Usage and Synthesis.

Analgesia: It has obvious analgesic effects on a variety of pain models, including electric stimulation, hot plate method, photothermal stimulation and acetic acid twisting method caused by the pain response in mice. Its pathways of action include analgesic effects on the centre and inhibition of prostaglandin synthesis and release.
Anti-inflammatory: It can significantly reduce the increase of vascular permeability induced by 5-HT, and has obvious inhibitory effect on the swelling of the toe of rats induced by carthamus tinctorius. It has obvious improvement effect on rat adjuvant arthritis model and can significantly reduce the systemic lesions in rats.
Immunomodulation: It has significant inhibitory effect on the synthesis of cytokines IL-1, IL-2, IL-6 and TNF by human peripheral blood mononuclear cells, significantly reduces phagocytosis rate of mouse macrophages, and significantly inhibits the synthesis of inflammatory mediators PGE2, LTC4 and Nitrogen oxides. It has anti-T-lymphocyte proliferation and synovial membrane proliferation effects, and can inhibit the body's immune rejection reaction.
Sedation: it can significantly reduce the spontaneous activity of mice, and has no significant effect on the sleep time of barbiturates, and has an antagonistic effect on strychnine, but cannot oppose pentamethylene tetrazolium. Dogs and monkeys orally administered with 45-95mg/kg of the drug also have obvious sedative effects, and can eliminate the ‘irritation’ reaction induced by electrical stimulation in mice.

Uses of Sinomenine Hydrochloride.

Sedation: It can significantly reduce the spontaneous activity of mice, and has no obvious effect on the sleep time of barbiturates; it has antagonistic effect on strychnine, but cannot oppose pentamethylene tetrazolium. Dogs and monkeys orally administered with 45-95mg/kg of the drug also have obvious sedative effects, and can eliminate the ‘irritation’ reaction caused by electrical stimulation in mice.
Cough suppressant: In mice (SO2 method) and cats (electrical stimulation of the superior laryngeal nerve method), its cough suppressant effect is similar to that of codeine.
Antihypertensive: Injecting 0.27mg/kg of this product into dogs, it has obvious acute antihypertensive effect, and the second injection can produce rapid tolerance.

Key Benefits of Sinomenine Hydrochloride

Core Benefits	Mechanism of Action and Explanation	Applicable people
1. Anti-Inflammation and Analgesia	This is more than just a simple painkiller. It reduces inflammation at its source by inhibiting the production of key inflammatory factors (such as TNF-α, IL-1β, and IL-6), thereby alleviating the pain, swelling, and stiffness caused by inflammation.	It is suitable for patients with autoimmune arthritis, such as rheumatoid arthritis and osteoarthritis. They need a medication that controls the root cause (inflammation), not just a temporary pain mask.
2. Immunosuppression	This is one of its most unique and important effects. It inhibits the overactivation of T and B lymphocytes, the main force in the immune system's attack on self-tissues. This effectively cools down an overactive immune system.	It is targeted at patients with autoimmune diseases (such as rheumatoid arthritis). Their core pain point is immune system dysfunction, and they need a medication that helps regulate immune balance, not just anti-inflammatory treatment.
3. Anti-fibrosis	Studies have shown that sinomenine can inhibit fibroblast proliferation and excessive collagen deposition, which theoretically holds promise for the treatment of organ fibrosis (such as pulmonary and liver fibrosis).	This benefit is still under investigation, but offers hope for the future for patients.
4. Kidney Protection	In animal models of diabetic nephropathy, it has demonstrated the potential to mitigate renal damage through anti-inflammatory and anti-fibrotic effects.	This is also a cutting-edge research area, demonstrating its multifaceted potential.

Sources of Sinomenine Hydrochloride:

1. Natural Plant Source

Primary Plant: Sinomenium acutum, a traditional Chinese medicinal herb with a long history of use in China and Japan.

2. Modern Pharmaceutical Production

Extraction and Synthesis: Modern pharmaceutical industry utilizes advanced extraction, separation, and purification technologies to obtain high-purity sinomenine from Sinomenium acutum. This is then salted with hydrochloric acid to produce the sinomenine hydrochloride API. Finally, it is manufactured into dosage forms such as tablets and injections.

Important Notes:

This is a prescription medication, not a dietary supplement. Sinomenine hydrochloride is a pharmacologically active drug and must be used under the guidance and supervision of a physician. Do not purchase or take it on your own.
Potential Side Effects: Like all medications, it has side effects. These may include rash, itching, gastrointestinal discomfort, and leukopenia. Your doctor will require regular monitoring of blood counts and liver function during use.
Contraindications: Pregnant and breastfeeding women, those with severe heart disease, or those with liver or kidney dysfunction should avoid or use with caution. Be sure to explain your medical condition to your doctor in detail.
Don't confuse with plant-based ingredients: Although it comes from a plant, using Sinomenine hydrochloride directly cannot accurately control dosage and may contain other unknown ingredients, posing safety risks.

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