raw Materials powder Robenidine Hydrochloride

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Robenidine Hydrochloride powder Usage and Synthesis.

(1) Poultry chlorphenguanidine has been widely used as an anti-coccidium drug for chickens in China, and the feed concentration of 60mg/kg has good control effect on tender, toxic, Brucella, giant, pile type and alleviating the single or mixed infection of early Eimerball. The effect on toxic and mild Eimeria is similar to that of chloropyridine (125mg/kg). The prevention effect of Eimeria brucei against tender, compost, giant, is better than that of chlorpyridine.

According to experiments, feeding chickens with low drug concentration (30mg/kg) does not affect the host's immunity to coccidia, but affects the anti-coccidia effect. Therefore, the concentration of 60mg/kg is still appropriate for outbreak of acute coccidiosis.

(2) In addition to the slightly poor effect on Eimeria intestinalis, rabbit chlorphenguanidine has a good control effect on most Eimeria immune (such as Eimeria medium and Eimeria non-residual). 

Uses of Robenidine Hydrochloride.

The new effective anticocciditic drug has high curative effect, low toxicity and good palatability. It has good effect on acute or chronic coccidiosis of chicken. To investigate the weight gain rate and feeding reward of rabbits and birds. The product is a variety of animal Pharmacopoeia of the People's Republic of China (90 edition, a).

Chlorphenguanidine is a low-toxicity and highly effective anticoccidium drug, which can be used in chicken feed with the dosage of 30-36g/t. It should be prohibited during egg production and the drug withdrawal period should be 7 days. It can also be used for rabbit feed, the dosage is 50-66g/t, prohibited during pregnancy, and the drug withdrawal period is 7 days.

As an antibacterial agent, it is effective against staphylococcus and hemolytic streptococcus. It is mainly used for the treatment of avian cholera, avian typhoid, and avian fall worm disease.

The anticoccidiosis drug has good effect on acute or chronic coccidiosis of chicken.

Pharmacological action of Robenidine Hydrochloride.

Chlorobenzidine is a guanidine derivative. It has been widely used in the prevention and control of coccidiosis in birds and rabbits.

The anti-coccidian mechanism of chlorphenguanidine is to affect adenosine triphosphate and interfere with coccidian protein metabolism.

The peak of the action of chlorphenguanidine on coccidia was mainly in the first generation schizozoite stage, which could prevent the schizozoite from forming schizozoites. In addition, it has been confirmed that it also has an inhibitory effect on the second generation of schizozoites, and even has an inhibitory effect on oocyst development.

Product Methods of Robenidine Hydrochloride.

Thiosemicarbazone is formed by addition and rearrangement of sodium thiocyanate with water and hydrazine. Then N.N' -diaminoguanidine sulfate is obtained by methylation and hydrazine hydrolysis with dimethyl sulfate. N.N' -diaminoguanidine hydrochloride was replaced by calcium chloride. Finally, chlorphenguanidine hydrochloride was synthesized by condensation with p-chlorobenzaldehyde and ethanol, the yield was 94%.

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