pharmaceutical intermediate Cantharidin raw powder
pharmaceutical intermediate Cantharidin raw powder
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pharmaceutical intermediate Cantharidin raw powder

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Cantharidin Usage and Synthesis.

The cytotoxic effect of norcantharidin on HL-60 cell line was detected by in vitro cell culture technique and 3H-thymidine nucleoside release method. The results showed that the cytotoxic effect of norcantharidin on HL-60 cell line was dependent on concentration and time. Sodium cantharidate can inhibit the solid type of mouse sarcoma S180, cervical cancer 14 and ascites carcinoma, while hydroxycantharidin can inhibit the reticulocytic sarcoma of ascites carcinoma, hepatocellular carcinoma L16 cells and lung cancer D6 cells. Cantharidin can damage mitochondrial structure and affect the structure of NADHD and CCO located on it. According to the clinical application results, cantharidin is effective for primary liver cancer, which can stabilize the disease, prolong the survival period, and shrink the liver mass in some cases. It is also effective for lung cancer, esophageal cancer, colon cancer and breast cancer. But its toxicity is greater, the digestive tract and urinary system has a stimulating effect, individual can cause tachycardia, finger and face numbness. Severe gastrointestinal ulcer, bleeding tendency, cardiac and renal insufficiency, pregnant women should not use. Preparations include cantharidin tablets and cantharidin injection.

Cantharidin powder

Uses of Cantharidin.

Antitumor drug, mainly used in primary liver cancer, often used in combination with other antitumor drugs. Intermediate of hydroxycantharidin.

Cantharidin

Pharmacological action of Cantharidin.

1. Traditional Chinese medicine: foaming, diuretic and other functions.

2. Anti-cancer effect:

(1) Inhibiting protein synthesis in cancer cells and thus affecting RNA and DNA synthesis.

(2) To reduce the level of cancer hormones, mainly to reduce the activity of cyclic guanosine phosphodiesterase.

(3) Increase the content of interleukin II produced by spleen lymphocytes and interleukin I produced by macrophages, thereby improving the immune capacity of the body.

3. Clinical and experimental results of other pharmacological activities also show that cantharidin can inhibit pathogenic skin fungi but has little effect on some refractory skin. It can also stimulate DNA synthesis of bone marrow cells and cause the increase of leukocytes in the body, thus antagonizing the side effects of leukocyte decline caused by chemotherapy. At the same time, cantharidin also has the function of promoting estrogen.

Cantharidin raw

Product Method of Bulk Cantharidin.

It can be extracted from insect cantharides and synthesized chemically.


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