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4,7-Dichloroquinoline Powder is a white needle-like crystalline solid with a melting point of 84~86°C.
Dichloroquinoline Powder is an important pharmaceutical intermediate, Dichloroquinoline Raw Material is used for the synthesis of hydroxychloroquine sulfate, a drug for the treatment of discoid lupus erythematosus and systemic lupus.
Dichloroquinoline Raw Material is used in the synthesis of hydroxychloroquine sulfate for the treatment of discoid lupus erythematosus and systemic lupus erythematosus.
4,7-Dichloroquinoline Powder is an important pharmaceutical intermediate for the anti-malarials Chloroquine Phosphate, Hydroxychloroquine Sulfate, Amodiaquine, etc. It is usually obtained by chlorination and isolation of 7-chloro-4-hydroxyquinoline. Used as intermediate of drug Chloroquine phosphate.
Uses and functions of 4,7-Dichloroquinoline Powder
4,7-Dichloroquinoline is an important intermediate of anti-malarial drugs such as chloroquine phosphate, hydroxychloroquine sulfate, amodiaquine, etc. It is usually obtained from 7-chloro-4-hydroxyquinoline by chlorination and separation.
Pharmacological Effects of 4,7-Dichloroquinoline Powder
4,7-Dichloroquinoline is used in the synthesis of heteroaminoquinoline-triazine derivatives with antimicrobial activity. In addition, it has been used in the synthesis of novel oxazolidinones as antimicrobial agents, which show potent efficacy against common bacterial strains. Chloroquinoline impurity.
Uses Used as an intermediate in the drug chloroquine phosphate Production method Chlorination of 7-chloro-4-hydroxyquinoline.
Production method of 4,7-Dichloroquinoline Powder.
Reaction bottle add 300g of toluene, N,N-dimethylformamide 5g, triphenylphosphine 5g, 7-chloro-4-hydroxyquinoline 100g, turn on the stirring, warm up to 50 ℃ ~ 100 ℃. Prepare 287g of toluene solution of 23% triphosgene, dissolve completely clear and place in a constant pressure dropping funnel.
Maintain the temperature in the reaction bottle 50 ℃ ~ 100 ℃, slowly add 23% of the toluene solution of three light gas drop, control the drop time for 1 ~ 8 hours. After the dropwise addition, the reaction was continued until the completion of the reaction was monitored by TLC (about 1 to 3 hours reaction completion). After the completion of the reaction at 50 ℃ to 100 ℃ decompression distillation, to be decompression distillation until the condenser no obvious droplets and then stop distillation. Add 300g of anhydrous ethanol and 1~5g of activated carbon under stirring, and raise the temperature to reflux decolorization for 1 hour.
The filtrate was filtered while hot, then cooled down to 10℃-30℃ and filtered to obtain the filter cake, which was washed with 10-50g of anhydrous ethanol and drained, and the wet product was dried under reduced pressure at 60℃ to obtain 4,7-dichloroquinoline.
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