Meglumine Powder N-Methyl-D-glucamine Raw Materials Powder

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Meglumine Raw Materials Selecting a suitable equilibrium ion for a drug is particularly important for improving solubility and bioavailability.N-Methyl-D-glucamine Raw MaterialsDiagnostic drugs, co-solvents for contrast media, surfactants

Meglumine Raw Materials (N-methyl-D-glucosamine), also known as glucosamine, is an aminosugar derived from sorbitol, stable at room temperature and pressure, with the appearance of a white crystalline powder. N-Methyl-D-glucamine Raw Powder is almost odourless, with a slightly sweet, salty and astringent taste, soluble in water, slightly soluble in ethanol and almost insoluble in chloroform.

Uses and functions of N-Methyl-D-glucamine Raw Powder.

N-Methyl-D-glucamine Raw Powder is used as a medical contrast agent and surfactant. N-Methyl-D-glucamine Raw Materials can be used in the formulation of the contrast agent drugs panaglumine and cholestyramine (co-solubilising agent), and is also used as an excipient or intermediate in other drugs. Glucosamine is an aminosugar derived from sorbitol, containing amino, primary and secondary hydroxyl groups.

Pharmacological Effects of Purity Meglumine Powder.

Meglumine Powder is White crystalline powder. Melting point 128-129°C. Easily soluble in water, slightly soluble in ethanol (in 100ml ethanol, 1.2g soluble at 25℃, 21g soluble at 70℃), almost insoluble in chloroform. Taste slightly sweet and salty astringent.

Production method of Meglumine Raw Materials Powder.

It is obtained by condensation of glucose with monomethylamine followed by catalytic hydrogenation. Anhydrous ethanol and dry glucose were added to the reaction pot, and dry monomethylamine gas was passed at 50°C. After 1.5-2h of reaction, the solution was gradually clarified, and continued to be kept at 50°C for 2h to obtain glucose condensed methylamine solution.

Then it was added into the autoclave and pressurised to 2.5MPa by hydrogen passage in the presence of Reynolds' nickel and stirred for 1-2h at 80-85°C. The solution was then cooled and depressurised and discharged.

Then it was discharged after cooling and pressure relief, and the upper layer of glucosamine ethanol solution was cooled and crystallised, filtered to obtain the crude product of glucosamine, and then refined to obtain the finished product.

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