Pharmaceutical Bulk Cholesterol Powder

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Cholesterol Powder Usage and Synthesis.

1.Cholesterol can be used as emulsifier, artificial oxalic acid, vitamin D, liquid crystals, synthetic hormone raw materials, but also used as an analytical control for biochemical research.

2. It can also be used in brain phospholipid cholesterol flocculation test. Cholesterol is the main component of biofilm, about 25% of total ceruloplasmin is cholesterol.

Uses and functions of Bulk Cholesterol Powder.

(1) Involved in the formation of cell membranes.

(2) Cholesterol is the raw material for the synthesis of bile acids, vitamin D, and steroid hormones.

(3) The amount of total cholesterol in the blood serum of a normal Chinese person is about 182.5±4.3 mg%. Excessive blood cholesterol level indicates that cholesterol metabolism may be impaired. Patients with coronary atherosclerosis tend to have high serum cholesterol levels. Therefore, determination of serum cholesterol levels on clinical laboratory tests will help in the diagnosis of certain diseases.

Pharmacological Effects of Bulk Cholesterol Powder.

Physical Properties

Density: in water, 0.095mg/l at 30°C

Melting point: 148.5°C

Boiling point: 360°C at 760mmHg pressure

Solubility: moderately soluble in hot alcohol; soluble in aqueous solutions of benzene, oil, fat and bile salts [1]

Chemical Properties

Cholesterol is composed of a steroidal part and a long side chain.

Cholesterol-modified peptide drugs can increase the drug activity and in vivo/ex vivo half-life of peptides, have weaker toxic side effects, and also cross the blood-brain barrier.

Production method of Cholesterol.

Livestock brain tissue as raw material dry brain powder preparation take fresh animal brain and spinal cord (remove fat and spinal cord membrane), crushed, 40-50 ℃ drying, get dry brain powder. Brain (pig, cow, sheep) [40-50 ℃] → dry brain powder crude cholesterol crystals preparation of dry brain powder add 1.2 times the amount of acetone impregnation, constant stirring, extraction 4.5h, repeated extraction 6 times, filtration, combined with the extract, distillation and recovery of acetone, get yellow solid material.

Add 10 times the amount of ethanol, heating reflux 1h, cholesterol ethanol solution, filtration, filtrate at 0-5 ℃ cooling, standing, precipitation of crystals, filtration, crude cholesterol crystals. Dry brain powder [acetone] → yellow solid [ethanol] → cholesterol ethanol solution [0-5 ° C] → crude cholesterol crystals refined cholesterol preparation take crude cholesterol crystals plus 5 times the amount of ethanol, add 5% -6% sulfuric acid, heating reflux 8h, hydrolysate, cooling at 0-5 ° C, dialysis of the crystals, filtration, the crystals, plus ethanol wash to neutral. Will be washed to neutral crystals plus 10 times the amount of 95% ethanol, add 3% activated carbon, heating reflux decolourisation 1h, insulation filtration, filtrate 0-5 ℃ cooling crystals, repeated for 3 times, filtration, collection of crystals, pressure drying, evaporate ethanol, 70-80 ℃ vacuum drying, to get refined cholesterol.

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