Irbesartan Raw Material Irbesartan Powder

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Irbesartan Raw Materials Usage and Synthesis

Supply Purity 99% Irbesartan Raw Material, High Quality Supply Irbesartan Raw Powder Factory Supply Irbesartan Powder Raw Manufacturer of Supply Irbesartan Powder Raw Materials. Irbesartan Raw Material is a new blood pressure-lowering drug, a specific angiotensin II receptor (AT type I) antagonist, Irbesartan Powder used in the treatment of essential hypertension.

Irbesartan, as a long-acting antihypertensive drug, is the first-line drug for hypertension, and in addition to the treatment of hypertension, for Parkinson's, diabetic nephropathy, and other diseases have embodied notable efficacy.

Uses and functions of Irbesartan Powder

Irbesartan Powder is an antihypertensive drug. Angiotensin II-l type (AII1)-receptor antagonist. Irbesartan Raw Powder Used in the treatment of hypertension.

Pharmacological Effects of Irbesartan Raw Powder

There are no significant interactions between Irbesartan and hydrochlorothiazide, digoxin, warfarin, or nifedipine. When used in combination with diuretics, care should be taken to ensure that blood volume is insufficient or that hypotension can be caused by low sodium.

When combined with potassium-preserving diuretics (e.g. aminoglutethimide, etc.), elevated blood potassium should be avoided. Combination with digitalis analogues such as digoxin, beta-blockers such as atenolol, calcium antagonists such as nitrophenylpyridine, etc. does not affect the pharmacokinetics of each other.

Production method of Raw Irbesartan Powder

• Method 1: 1-(Fluorenylmethoxycarbonylamino)cyclopentanecarboxylic acid (I) was amidated to 4-(2-phenylcyano)benzylamine, and the product (Ⅲ) was then hydrolysed to remove the protecting group on N to give compound (Ⅳ). (IV) and triethyl orthobutyrate were condensed and cyclised to give compound (V), which was then reacted with sodium azide to form tetrazole to give irbesartan .

• Method 2: Condensation of 1-(fluorenylmethoxycarbonylamino)cyclopentanecarboxylic acid (I) and compound (Ⅳ), the product was obtained by removing the protecting group on N to obtain compound (Ⅷ), and then reacted with triethyl orthovalerate to obtain the product.

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