Malotilate Raw Material Viaminate Powder

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China Malotilate Raw Material Malotilate Powder Factory Supply Malotilate Raw Material, High Quality Malotilate Powder Purity 99% Malotilate Raw Powder CAS 59937-28-9. Malotilate Powder (NKK105) is a hepatic protein metabolism improver.

Uses and functions of Malotilate Powder

Hepatic protein metabolism improvement drug. It can activate liver function and inhibit the progress of liver fibrosis.

It is suitable for the treatment of chronic hepatitis, compensated cirrhosis and advanced schistosomiasis-induced cirrhosis with hypoproteinaemia.

Uses Hepatitis adjuvant for the improvement of liver function in compensated cirrhosis.

Pharmacological Effects of Malotilate Raw Powder

Malotilate increased collagenase activity in a concentration-dependent manner over a concentration range of 0.1 to 100 μM, without affecting monolayer cells.

In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, and also did not affect monolayer cells.

Malotilate significantly reduced the invasion of RLE monolayers by C-SST-2 cells.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation.

Malotilate inhibits tumour metastasis by enhancing intercellular contact of endothelial cells, thereby preventing tumour cell invasion into the vascular endothelium.

Production method of Raw Malotilate Powder

Diisopropyl malonate and carbon disulphide were reacted in dimethyl sulfoxide in the presence of potassium hydroxide. The product obtained and 1,1,1-trichloroethane, reacted in the presence of potassium hydroxide to give malotilate.

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