Omeprazole magnesium Raw Materials Powder

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Omeprazole magnesium Powder Usage and Synthesis.

Omeprazole magnesium, the name of a western medicine. Common dosage forms include enteric-coated tablets. It is a proton pump inhibitor and is used for the short-term relief of heartburn and acid reflux symptoms caused by excess stomach acid.

Uses and functions of Progesterone.

Omeprazole can inhibit the secretion of gastric acid, clinically used for heartburn and acid reflux caused by excessive gastric acid. In addition, Omeprazole magnesium enteric-coated tablets, treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: co-administered with antibiotics for the treatment of duodenal ulcer infected with Helicobacter pylori; treatment of peptic ulcers and gastro-duodenal eruption related to non-steroidal anti-inflammatory drugs (NSAID); prevention of symptoms of peptic ulcers, gastro-duodenal eruption, or indigestion induced by NSAIDs; also used in the chronic recurrent peptic ulcers Long-term treatment of chronic recurrent peptic ulcers and reflux oesophagitis; symptomatic treatment of heartburn and reflux in gastro-oesophageal reflux disease (GERD); symptomatic treatment of ulcer-like symptoms and acid-associated dyspepsia; treatment of Drexler-Ehrens Syndrome.

This product is used for the short-term relief of heartburn and acid reflux symptoms caused by excessive stomach acidity

Pharmacological Effects of Omeprazole magnesium.

Omeprazole is absorbed in the small intestine and is usually completely absorbed within 3-6 hours. Bioavailability after repeated administration is approximately 60%. Simultaneous ingestion of food has no effect on its bioavailability. Omeprazole has a plasma protein binding of 95% and an apparent volume of distribution of 0.3 L/kg.METABOLISM: Omeprazole is completely metabolised in the liver, mainly by CYP2C19 and CYP3A4 enzyme-catalysed metabolism. Its metabolites are sulfone, sulfide and hydroxy omeprazole, which have no significant effect on gastric acid secretion. Total plasma clearance is 0.3-0.6 L/min. omeprazole inhibits its own catalytic metabolism by CYP2C19, thus increasing the bioavailability of omeprazole by approximately 50% with multi-dose therapy compared to single-dose therapy. EXHAUSTION: The plasma elimination half-life of omeprazole is approximately 40 minutes (30-90 minutes). Approximately 80% of the metabolites are excreted in the urine and the remainder in the faeces. PATIENT FACTORS: The bioavailability of omeprazole is not significantly altered in elderly patients or patients with renal hypoplasia, and is elevated in patients with hepatic impairment, but clearance is significantly reduced in all of these patients

1、Concomitant use with oral imidazole antifungal drugs such as ketoconazole, itraconazole, miconazole and fluconazole should be avoided.

2, Omeprazole and clarithromycin co-administration can increase the incidence of central nervous system (mainly headache) and gastrointestinal adverse reactions.

3、Concomitant use with diazepam (Valium), phenytoin, warfarin, nifedipine, digoxin, cisapride, quinidine, cyclosporine, caffeine and theophylline should be avoided.

4, if used with other drugs may occur drug interactions, please consult your physician or pharmacist for details.

Production method of Bulk Omeprazole magnesium Powder.

Tablets must be swallowed whole and taken with at least half a glass of liquid. Tablets must not be chewed or crushed, but may be dispersed in water or a slightly acidic liquid (e.g. fruit juice); the dispersion must be taken within 30 minutes

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