Bulk Raw Materials Carnosine Powder

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Carnosine Powder Usage and Synthesis.

Carnosine, or β-alanyl-L-histidine, is a crystalline solid dipeptide composed of two amino acids, β-alanine and L-histidine. Muscle and brain tissues contain high concentrations of carnosine. Carnosine was discovered along with carnitine by the Russian chemist Gulevich. Studies in the United Kingdom, South Korea, Russia and other countries have shown that carnosine has a strong antioxidant capacity and is beneficial to the human body. Carnosine has been shown to remove reactive oxygen species (ROS) and α-β-unsaturated aldehydes that are formed by excessive oxidation of fatty acids in cell membranes during oxidative stress.

Uses of Carnosine.

L-carnosine can be used as a cell antioxidant, maintain pH balance and prolong cell life

Levocarnosine has potential antioxidant and anti-glycosylation activity. Block acetaldehyde induced non-enzymatic glycosylation and protein coupling. It is also a substrate for carnosinase detection, which can maintain pH balance in the body and extend cell life

Levocarnosine is a dipeptide with strong antioxidant and anti-glycation activity; Block non-enzymatic glycosylation and protein crosslinking induced by reactive aldehydes.

Scope of application of Carnosine.

New food additives. Carnosine is a dipeptide composed of β-alanine and histidine, which can be synthesized in animals. 3, carnosine has a significant inhibitory effect on lipid oxidation caused by free radicals and metal ions, and carnosine can inhibit fat oxidation and protect meat color in meat processing. Carnosine and phytic acid resist beef oxidation. The addition of 0.9g/kg carnosine to the diet can improve the color of flesh and the oxidative stability of skeletal muscle, and has a synergistic effect with vitamin E.

4. The use of cosmetics can prevent the aging of the skin and the whitening of the skin, carnosine can prevent the emergence of free radicals caused by smoking, and this free radicals will harm the skin more than sunlight, free radicals are very active atoms or atomic groups in the human body, can oxidize other substances in the human body.

5. Carnosine has antioxidant properties and is a natural antioxidant.

6. The transmittance of cloudy human eye crystals is enhanced. Senile cataract can be treated with carnosine based antioxidant preparations.

7, olfactory nerve sensor, can promote wound healing, especially used in surgical treatment of oral medicine.

Preparation method of Carnosine Powder.

A) To prepare hydrazine hydrolysis reaction solution, put 50g(0.14mol) of phthalyl-L-carnosine as intermediate, 200ml of water, and 10.8g(0.17mol) of hydrazine hydrate (80% mass percentage concentration) into a 1000ml four-mouth reaction bottle, and heat until the reflux reaction is 1.0h. Add acetic acid to adjust the pH of the material to 5.5, filter out the by-products, and obtain hydrazine hydrolysis reaction liquid:B) To prepare L-carnosine, add 100ml dichloromethane and 9.6g(0.09mol) benzaldehyde into the hydrazine hydrolysis reaction solution obtained from step

A), stir at room temperature for 12h, then stratified the material, separate the dichloromethane layer, wash the water layer twice with 50ml dichloromethane, and add 3g activated carbon and 25ml ammonia water (18%). Decolorization was performed at 60℃ for 0.5h, activated carbon was filtered out, the decolorization solution was concentrated in vacuum until solid precipitated, 300ml methanol was added for crystallization, stirred for 2.0h and filtered, and 28.6g L-carnosine product was obtained after the cake was dried at 100℃ for 6h. No residue of hydrazine was detected in the product.

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