High Quality Bulk Mangostin Powder

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Mangostin Powder Usage and Synthesis.

Alpha-mangostin is a dietary xanthone with a wide range of biological activities such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of IDH1 mutant (IDH1-R132H) with a Ki value of 2.85 μM.

Uses and functions of  Palmatine.

α-Inverted Twist has been shown to be useful in the treatment of diarrhoea, malaria, anti-inflammatory, anti-ulcer, and anti-leukaemia and septicaemia.

Pharmacological Effect of  Mangostin.

1、Inhibition of cyclooxygenase

Cyclooxygenase is involved in a variety of pathophysiological processes, its high expression on inflammation, pain, cardiovascular disease, Alzheimer's disease, cancer, the occurrence and development of all stages of the promotion of the role of obvious. γ - invertin can be combined with the active point of the cyclooxygenase, can be completely inhibited by cyclooxygenase activity. α - invertin also inhibit the activity of the cyclooxygenase, the range of inhibitory concentrations similar to that of the γ - invertin.

2, Phytoestrogen-like effect

The biological effect of phytoestrogens is mainly manifested in hormone-related diseases, such as breast cancer, cardiovascular disease, osteoporosis, menopausal syndrome, etc. α-invertin has therapeutic effect on hormone-related diseases.

3、Apoptosis

The apoptotic effect of α-invertegrin makes it provide a new way for the immunotherapy of leukaemia.

4、Inhibition of neurosphingosine phosphatase

Neurosphingosine phospholipase is the hydrolase of nerve sheath phospholipids, which is involved in the regulation of cell growth, differentiation, apoptosis and other processes. It has a great relationship with the occurrence of intestinal tumours. α- can inhibit the activity of neurosphingosine phospholipase.

5、Antioxidant effect

The oxidation of low-density lipoprotein is very harmful to cardiovascular disease and other chronic diseases.

7、Anti-cancer:α-invertebrate is involved in protein kinase phosphorylation of various oncogenic processes, including cancer cell proliferation, apoptosis, angiogenesis and metabolism, and on the in vivo and in vitro cultured tumour cells have a certain degree of inhibition. γ-Invertebrate can inhibit the mitochondrial catalase production of reactive oxygen species in U87MG and GBM8401 cells, so as to achieve the inhibition of tumour cell growth and promote apoptosis, therefore, it can inhibit the growth of cancer cells and promote apoptosis. γ-Invertsin can inhibit U87MG and GBM8401 cell mitochondrial hydroxylase to produce reactive oxygen species, so as to inhibit the growth of tumour cells and promote the apoptosis of cancer cells, therefore γ-Invertsin can be used to develop into the antitumour drugs with great potential as a precursor compound.

8, the role of the treatment of breast cancer

The higher the content of α- and γ-invertin, the better the inhibitory effect of the same total extract on breast cancer cells. Invertin can change the cellular morphology of breast tumour cells and their dividing DNA fragmentation.

9、Histamine H1 receptor antagonistic effect

Inflammatory mediator histamine can induce allergic asthma and bronchospasm. α-Invertebrate is a selective and competitive antagonist of histamine H1 receptor.

10、5-Hydroxytryptamine 2A receptor inhibitory effect

5-hydroxytryptamine 2A (5-HT2A) receptor and cardiovascular disease, 5-HT has a strong vasoconstriction and promote platelet aggregation function. γ-inverted Twistorin can inhibit platelet aggregation.

11、Antibacterial effect

α-Invertebrate has strong antibacterial activity against Staphylococcus aureus which is sensitive to methicillin and toluene penicillin. α- and β-Invertebrate have strong inhibitory effect on Mycobacterium tuberculosis.

12, there are researchers found that α-invertebutin on Canadian albinism has a significant therapeutic effect; α-, γ-invertebutin also has anti-inflammatory, chemical hypoxia resistance, analgesic, hypoglycaemic effect and other biological activities.

Test conditions of  Bulk Mangostin Powder.

The separation was carried out on a Shimadzu chromatograph with a YMC-ProC18 150*4.6mm 5um 80Å column, using methanol:water (40:60 ratio) as the mobile phase with a quadratic gradient elution, and detected by a UV detector at 280 nm. Dissolution in methanol

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