API Raw Materials α-Lipoic Acid Powde

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α-Lipoic Acid Powder Usage and Synthesis.

In the field of medicine, alpha lipoic acid is widely used in the prevention and adjuvant treatment of diabetes and its related complications. It can enhance glucose metabolism, attenuate oxidative stress, alleviate the symptoms of diabetic neuropathy, prevent diabetic cataracts, and prevent diabetic cardiovascular damage.

Physicochemical Property of α-Lipoic Acid.

The appearance of α-lipoic acid is light yellow powdery crystal, almost odourless, the chemical structure is 6,8 a two DL-lipoic acid, in 6,8 carbon between the disulfide bond connected to the formation of endodisulfide compounds. Be also Chemicalbook original, disulfide bond broken to form dihydro DL-lipoic acid. alpha-lipoic acid is insoluble in water but soluble in fat solvents, some people listed as fat-soluble vitamins; in methanol, ethanol, chloroform, ether soluble.

Uses of α-Lipoic Acid.

Antioxidants and as coenzymes of e.g. pyruvatedehydrogenase and glycine decarboxylase, exogenous lipoic acid is reduced by two or more enzymes within the cell. This reduced form affects the cellular process of free radical scavenging. Increases glutathione (glutathione) synthesis and regulates transcription factor activity. Decreased phagocytosis of macrophage myelin.

Vitamin analogue that stimulates fat metabolism. Used in the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes mellitus and other diseases and therapeutic health care.

Biochemical functionof  Bulk α-Lipoic Acid Powder.

DL-Lipoic acid is an antioxidant that can deliver hydrogen through inter-transformation between oxidised and reduced forms. The body can synthesise the required amount of DL-lipoic acid. At present, no deficiency of DL-lipoic acid has been detected.DL-lipoic acid (1ipoicacid) is a sulphur-containing octacarboxylic acid that exists in both oxidised and reduced forms. In nature DL-lipoic acid exists bound to proteins with its carboxyl group attached to the --NH of lysine in the protein molecule.

DL-lipoic acid is an acyl carrier, present in pyruvate dehydrogenase and a ketoglutarate dehydrogenase, and is closely related to glucose metabolism. Oxidised and reduced DL-lipoic acid interconverting acids function as coupled acyl transfers and electron transfers during oxidation and decarboxylation of a keto acids.DL-lipoic acid is widely distributed in nature and is particularly abundant in liver and yeast. It is often found in foods along with vitamin B.

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