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1. Chondroitin sulphate has been used as a health food or health care drug for a long time in the prevention and treatment of coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, with no obvious toxic side effects, and it can significantly reduce the morbidity and mortality rate of patients with coronary heart disease. Long-term clinical application found in the arteries and veins wall deposits of fat and other lipids can be effectively removed or reduced, can significantly reduce plasma cholesterol, thus preventing the formation of atherosclerosis.
2. Chondroitin sulphate is used in the treatment of neuralgia, neurogenic migraine, arthralgia, arthritis and scapular joint pain, pain after abdominal surgery.
3. It is effective in preventing and treating the hearing disorder caused by streptozotocin as well as the hearing difficulty and tinnitus caused by various noises.
4. It has auxiliary therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcer, etc. 5. In recent years, it has been reported that chondroitin in shark cartilage has anti-tumour effect. In addition, chondroitin sulfate is also used in cosmetics and wound healing agents.
6. Chondroitin sulphate is also used in eye drops.
Uses and functions of Chondroitin Sulfate.
1、Chondroitin Sulfate is a mucopolysaccharide extracted from animal cartilage, which has an important role in the prevention and treatment of cardiovascular diseases and joint diseases, and is a more important biochemical product in the market at present.
2, chondroitin sulfate as health food or health care drugs for long-term application in the prevention and treatment of coronary heart disease, angina pectoris, myocardial infarction, coronary artery atherosclerosis, myocardial ischemia and other diseases, without obvious toxic side effects, can significantly reduce the morbidity and mortality of patients with coronary heart disease. Long-term clinical application found in the arteries and veins wall deposits of fat and other lipids can be effectively removed or reduced, can significantly reduce plasma cholesterol, thus preventing the formation of atherosclerosis.
3、Chondroitin sulphate is used for the treatment of neuralgia, neuralgia migraine, arthralgia, arthritis, and scapular arthralgia, pain after abdominal surgery.
4、Preventing and treating streptozotocin-induced hearing impairment as well as all kinds of noise-induced hearing difficulties, tinnitus, etc., with remarkable effect.
5、It has auxiliary therapeutic effect on chronic nephritis, chronic hepatitis, keratitis as well as corneal ulcer, etc. 6、In recent years, it has been reported that chondroitin in shark cartilage has anti-tumour effect. In addition, chondroitin sulfate is also used in cosmetics and traumatic wound healing agents.
Chondroitin sulfate is an acidic mucopolysaccharide, one of the important components in eye tissue, with the promotion of corneal water metabolism and improve, applicable to visual fatigue, dry eye.
Pharmacological Effect of Chondroitin Sulfate.
Chondroitin sulphate is widely found in human and animal cartilage tissues. Its medicinal preparation mainly contains chondroitin sulphate A and chondroitin sulphate C two isomers, the content of chondroitin sulphate in the cartilage of animals of different species and ages is different. Its pharmacological effects are shown as:
1, chondroitin sulfate can remove lipids and lipoproteins in the blood of the body, remove cholesterol from the blood vessels around the heart, prevent and control atherosclerosis, and increase the conversion rate of lipids and fatty acids in the cells.
2, chondroitin sulfate can effectively prevent and control coronary heart disease. For experimental atherosclerosis model with anti-atherosclerosis and anti-atherogenic plaque formation; increase atherosclerosis coronary artery staging or collateral circulation, and can accelerate experimental coronary atherosclerosis or embolism caused by myocardial necrosis or degeneration of healing, regeneration and repair.
3, can increase the cellular messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) biosynthesis as well as has the effect of promoting cell metabolism.
4, low anticoagulant activity. Chondroitin sulfate has a mild anticoagulant effect, each lmg of chondroitin sulfate A is equivalent to 0.45U heparin anticoagulant activity. This anticoagulant activity does not depend on antithrombin III and play a role, it can play an anticoagulant activity through the fibrinogen system.
5, chondroitin sulphate also has anti-inflammatory, accelerate wound healing and anti-tumour effects.
Product Method of Bulk Chondroitin Sulfate Powder.
Porcine larynx and nasal cartilage were extracted with 2% sodium hydroxide, and the extract was hydrolysed with crude trypsin at 50°C to remove protein and other impurities. Filtration, enzyme hydrolysate adjusted pH to 6, add Chemicalbook ethanol to make ethanol concentration of 75%. Centrifugation to get the precipitate, that is, chondroitin sulfate crude product. The finished product was obtained by multi-step refining. For pig throat, nasal cartilage, the total yield of 5%.
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