Pharmaceutical raw material Vitamin B2 Riboflavin Powder

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Riboflavin Powder Usage and Synthesis.

Vitamin B2 (riboflavin) is a water-soluble vitamin that is easily digested and absorbed, and the amount excreted increases or decreases according to the body's needs and possibly the degree of protein loss; it does not accumulate in the body, so from time to time it has to be replenished with food or nutritional supplements.

Unlike vitamin B1, vitamin B2 is resistant to heat, acid and oxidation.

Clinically vitamin B2 tablets are used for the prevention and treatment of vitamin B2 deficiency, such as keratitis, dry and cracked lips, lingual inflammation, scrotal inflammation, conjunctivitis, seborrheic dermatitis, etc.; they are also used for the treatment of malnutrition, progressive weight loss and other diseases caused by total gastro-intestinal extra-nutritional and insufficient intake.

Uses and functions of Riboflavin.

Riboflavin exists in green vegetables, soybeans, rice, wheat, yeast, liver, heart and dairy, riboflavin in the body is distributed in the tissues, constituting a coenzyme in the body in the system of hydrogenation of the complementary hydrogenation, participate in redox reactions, play a role in the transmission of hydrogen atoms.

When riboflavin deficiency, it will affect the biological oxidation, so that the metabolism is impaired, resulting in lesions occurring in the mouth, eyes, external genitalia, such as stomatitis, labyrinthitis, conjunctivitis, scrotal inflammation and so on.

Riboflavin is mainly used as medicine, food additives and feed additives, in the medicinal aspect, used for multivitamin or vitamin B2 preparations, but also used as sugar-coated tablets and capsules of yellow colouring agent. When used as food additives, on the one hand, it has the effect of strengthening nutrition, on the other hand, it is also used as a yellow colouring agent. The LD50 for intraperitoneal injection in rats is 560mg/kg.

Vitamin B2 is a vitamin that promotes the growth and development of the organism and plays an important role in the metabolic process of the human body. When deficient, it is easy to suffer from conjunctivitis, keratitis, lingual inflammation and so on.

China's regulations can be used in table salt, the use of 100-150mg/kg; in solid beverages to make the maximum Chemicalbook dosage of 10-13mg/kg; in baby food for 4-8mg/kg; in cereals and their products in the use of 3.0-5.0mg/kg; in the drinking liquid, milk beverages, the use of 1-2mg/kg. also can be It can also be used as yellow colouring agent.

Specificities of Riboflavin Powder.

1, is easily destroyed by light (especially ultraviolet light).

2, is in the alkali solution can be destroyed by heating, so with food, drugs and should pay more attention;

3, is the body reserves are limited, must be replenished every day.

Product Method of Bulk Riboflavin Powder.

Vitamin B2 is naturally found in animal liver, kidney, meat and dairy foods, etc. It is produced industrially by fermentation and chemical synthesis methods.

Fermentation method to glucose, corn syrup, inorganic salts, etc. as a culture medium, with special active bacteria Alcian pseudocystic yeast (Eremotheciumashbyii) at 28 ℃ deep fermentation culture 9d, the fermentation broth contains about 6 ~ 8g / L riboflavin products. The extraction yield is 60% to 70%.

Synthesis method better synthesis method is first in Ph = 4 and 28 ~ 30 ℃ by 3,4-dimethyl aniline and D-ribose condensation, and then nickel-catalyzed hydrogenation reduction of ribonucleic acid amine, and then coupled with aniline diazonium salt at 16 ~ 26 ℃, and then reduced with sodium hyposulfite (insurance powder), and finally in acetic acid and barbituric acid (tetramethylpyrimidine) cyclic synthesis of vitamin B2.

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