Ferrous fumarate Raw Materials Ferrous fumarate Powder

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Ferrous fumarate Powder Usage and Synthesis.

Ferrous fumarate is absorbed in animals in the form of ferrous ions in the duodenum and upper jejunum.

Most of the absorbed iron is involved in the synthesis of haemoglobin in the bone marrow, while the remainder is stored as ferritin and ferric haemoflavin in the reticuloendothelial cells of the bone marrow, liver and spleen, and a further portion is present in the cells of the intestinal mucosa.

This absorption method is different from inorganic iron supplements (ferrous sulfate, ferrous carbonate and iron oxide, etc.), which can alleviate the competitive antagonism between the absorption of trace elements, will not destroy the vitamins, and will not catalyse oxidation reactions, and the nutrients with a good compatibility, and can smoothly pass the body absorption barrier, which not only greatly improves the absorption and utilisation of iron, but also improves the rate of absorption of other elements.

Iron is excreted mainly through the intestinal tract and the skin, with small amounts also excreted in the urine and sweat glands. Most of the iron can be reused when it is released after the haemoglobin molecule is destroyed.

Uses of Ferrous fumarate.

Ferrous fumarate, as a food iron fortifier, is better absorbed than inorganic iron.

Our country stipulates that it can be used in table salt and sandwich sugar, with a use level of 1800-3600mg/kg; 520-580mg/kg in high-iron cereals and their products (daily limit of 50g of such foods); 180-300mg/kg in dairy products and infant foods; 70-150mg/kg in cereals and their products; and 30-60mg/kg in beverages. kg.

Ferrous fumarate is an anti-anaemic drug.

Anaemia is divided into iron deficiency anaemia, megaloblastic anaemia and aplastic anaemia according to the different causes, ferrous fumarate is used for the treatment of iron-deficiency anaemia, with high iron content, good absorption, difficult to be oxidized into trivalent iron, the serum iron value rises very quickly after serving and can be kept stable.

The oral LD50 of mice is 480mg/kg.

Anti-anaemic drugs, used in the treatment of iron-deficiency anaemia, also used in food and feed additives.

Pharmacological Effect of Ferrous fumarate.

Iron is the main component of haemoglobin (the main oxygen-carrying component of red blood cells) and myoglobin (the site of oxygen storage in muscle cells, supplying oxygen during muscle movement). The ferrous ion of this drug is oxidised to trivalent iron ion by cuprocyanin in the blood, and then combines with transferrin in the plasma to be transported to various tissues in the body, and enters into the cells in the form of cytosolic drinking via the transferrin receptor to bind with protoporphyrin and bead protein on the mitochondria to form haemoglobin. It binds to protoporphyrin and bead protein on the mitochondria to form haemoglobin.

Most of the enzymes associated with the tricarboxylic acid cycle contain iron or function only in the presence of iron.

Therefore, in addition to accelerated haemoglobin synthesis, symptoms associated with tissue iron deficiency and reduced activity of iron-containing enzymes (e.g. growth retardation, behavioural abnormalities, lack of energy, changes in mucous membranes, and skin and nail lesions) are corrected in iron-deficient patients with active iron supplementation.

The high iron content of this drug (up to 33 per cent) and its difficulty in being oxidised result in fewer adverse effects and a quicker onset of action.

Product Method of  Bulk Ferrous fumarate Powder.

It is obtained by replacing sodium transbutylene diacid with ferrous sulphate. Heat water to boiling, add transbutylene succinate with stirring, add sodium carbonate to pH=6.5-6.7 in stages, stir well and filter while hot, get sodium transbutylene succinate solution. Add ferrous sulfate solution, stirring and heating reflux 3-4h, cooling crystallisation, shake filter. The filter cake is washed with distilled water until the sulfate meets the requirements, dry, get ferrous fumarate, yield 83%.

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