Turmeric Root Extract Curcumin Raw Materials Powder

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Curcumin Powder Usage and Synthesis.

Curcumin has a variety of pharmacological effects such as choleretic, anti-infectious, causing paroxysmal contraction of the uterus, lowering blood cholesterol, antiviral, antibacterial, antioxidant (stronger than α-tocopherol), anticoagulant, lipid-lowering, and anti-atherosclerotic.

Curcumin has protective effects in vitro and in vivo against various toxic substances such as carbon tetrachloride, aflatoxin B1, acetaminophen, cyclophosphamide-induced hepatic damage, and significantly reduces alkaline phosphatase and r-glutamyl transpeptidase (r-GT) activities in animals with alcoholic liver injury (ALI), preventing the occurrence of experimental fatty liver.

Uses of Curcumin.

Edible yellow colouring. It has been used in China for a long time for dried radish and curry powder. In Japan, it is used in pickles, ham, sausages and candied apples, pineapples and chestnuts.

Widely used in food, dishes, pastries, candy, canned beverages, as well as cosmetics, medicine colouring.

As a food colouring agent, it can be used in candy, jelly, ice-cream and carbonated beverages, and the maximum use level is 0.01g/kg.

Pharmacological Effect of  Bulk Curcumin Powder.

1. Choleretic: The product or its sodium salt has choleretic effect. When injected intravenously, it can reduce the content of solid components in dogs and increase bile secretion.

However, the absolute total amount of bile salts, bilirubin and cholesterol excreted increases and the fatty acid component remains constant throughout its bile secretion cycle.

2. Antibacterial: It has strong antibacterial effect on Staphylococcus aureus.

3. It can inhibit the gastric damage induced by intramuscular injection of 20mg/kg 5-hydroxytryptamine in guinea pigs when taken orally at 5～20mg/kg. It has protective effect on paracetamol-induced liver damage.

Product method of Curcumin.

Obtained by the reaction of vanillin with acetylacetone.

Dissolve vanillin with anhydrous ethyl acetate, then add tributyl borate and the complex generated from acetylacetone and B2O3, then add n-butylamine dropwise, stirring for 4-5h after dropping and leave overnight.

The following day, 0.4N hydrochloric acid at 60°C was added and stirring continued for 1h, and the reaction was kept warm with a 50°C water bath to complete the reaction.

Separate the aqueous layer of the reaction product, wash with water 3-4 times, filter out curcumin, wash with ethyl acetate 2-3 times to get the crude product, recrystallise with ethanol to get the finished product.

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