Dextran Raw Materials Dextran Powder

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Dextran Powder Usage and Synthesis.

β-Glucan is different from common sugars (such as starch, heparanose, dextrin, etc.), the main difference lies in the different bonding method, the molecular structure of common sugars is α-1,4-glycosidic bonded, while β-glucan is β-1,3-glycosidic bonded as the main body, and contains a number of β-1,6-glycosidic bonded branched chain.

β-Glucan is easily accepted by the immune system due to its special bond connection and the presence of intramolecular hydrogen bonds, resulting in a helical molecular structure, a unique conformation.

Uses and functions of Dextran.

Medium molecule dextrose is mainly used to increase plasma volume and maintain blood pressure, mainly for anti-shock. It is suitable for replenishing blood volume and maintaining blood pressure during massive blood loss.

Such as burns, trauma, trauma and other haemorrhagic and due to excessive blood loss caused by body shock first aid. Low molecular dextrose, mainly to improve microcirculation, used to prevent or eliminate intravascular red blood cell aggregation and thrombosis.

Small molecule dextran is similar to low molecule dextran in its role and use.

Blood volume supplementation. Adverse reactions and contraindications Occasional allergic reactions. Congestive heart failure and patients with bleeding disorders are prohibited, cardiac, hepatic and renal insufficiency should be used with caution.

Anti-anaemic drugs. For iron deficiency anaemia. Adverse reactions and contraindications If haemoglobin does not increase gradually after injection, the drug should be stopped immediately. Contraindicated in patients with hepatic and renal insufficiency.

Pharmacological Effect of Dextran.

The average molecular weight of dextran is about 7000, similar to that of human albumin, which can increase plasma colloid osmotic pressure and absorb extravascular water to supplement blood volume, thus maintaining blood pressure; it can depolymerise aggregated erythrocytes and platelets, and reduce blood viscosity, thus improving microcirculation and tissue perfusion, and preventing intravascular coagulation in the late stage of shock;

It can inhibit the activation of coagulation factor Ⅱ and reduce the activity of coagulation factor Ⅰ and coagulation factor Ⅷ, which can prevent thrombosis together with its anti-platelet effect. Dextran is stronger than dextrose-40 in expanding blood volume and antithrombotic effect.

Product Method of Bulk Dextran Powder.

Produced by fermentation and refinement of enteromembranous Streptomyces spp. using sucrose as the culture medium.

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